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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Role of nitric oxide on the vasorelaxant effect of atrial natriuretic peptide on rabbit aorta basal tone.
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Role of nitric oxide on the vasorelaxant effect of atrial natriuretic peptide on rabbit aorta basal tone.

机译：一氧化氮对心钠素对兔主动脉基调的血管舒张作用的作用。

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摘要

The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang II at 10(-8) M triggered a contractile response, conditioning the vessel to a vasorelaxant effect of ANP (10(-8) M). This effect was significantly enhanced by endothelium removal, NG-nitro-L-arginine methyl ester (L-NAME, 10(-4) M), and methylene blue (10(-5) M). ANP decrease of basal tone in Ang-II-sensitized aortic rings was improved when a higher concentration of Ang II was used (l0(-6) M). Basal and Ang-II-stimulated nitrite release were measured in stretched (S) and nonstretched (NS) aortic rings. Nitrite release was significantly increased in S rings (p < 0.001). L-NAME (10(-4) M) partially inhibited nitrite release in both basal and Ang-II-stimulated S aortic rings. In NS aortic rings, the NO inhibitor did not inhibit basal nitrite release but blunted the Ang-II-stimulated nitrite level. A significant negative correlation between nitrite release and the ANP vasorelaxant effect on basal tone was dependent on the Ang-II-sensitizing dose. The present results demonstrate that ANP relaxant effects on aortic basal tone are related to NO levels, which are regulated by S- and Ang-II-concentration-dependent NO generation and quenching.
机译：研究了一氧化氮（NO）对心钠素对血管紧张素II（Ang II）调节的兔主动脉环基音的血管舒张作用的作用。在存在和不存在内皮和一氧化氮合酶抑制剂的情况下测量ANP主动脉舒张和亚硝酸盐释放。 Ang II在10（-8）M触发收缩反应，使血管适应ANP（10（-8）M）的血管舒张作用。通过去除内皮，NG-硝基-L-精氨酸甲酯（L-NAME，10（-4）M）和亚甲基蓝（10（-5）M），可以显着增强该效果。当使用更高浓度的Ang II（10（-6）M）时，Ang-II敏感的主动脉环的基调ANP降低得到改善。在伸展的（S）和未伸展的（NS）主动脉环中测量基础和Ang-II刺激的亚硝酸盐释放。 S环中亚硝酸盐的释放显着增加（p <0.001）。 L-NAME（10（-4）M）部分抑制基础和Ang-II刺激的主动脉环中亚硝酸盐的释放。在NS主动脉环中，NO抑制剂不会抑制基础亚硝酸盐的释放，但会降低Ang-II刺激的亚硝酸盐水平。亚硝酸盐释放与ANP血管舒张作用对基音的影响之间显着的负相关性取决于Ang-II致敏剂量。目前的结果表明，ANP对主动脉基调的松弛作用与NO水平有关，NO水平受S和Ang-II浓度依赖性NO生成和猝灭的调节。

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