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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The kidney is resistant to chronic hypoglycaemia in late-gestation fetal sheep.
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The kidney is resistant to chronic hypoglycaemia in late-gestation fetal sheep.

机译：肾脏对妊娠晚期胎羊的慢性低血糖有抵抗力。

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We imposed a sustained reduction in glucose supply to late-gestation fetal sheep to see whether the reduction in glucose and insulin levels affected renal growth, renin expression and synthesis, and renal function. Maternal glucose concentrations were lowered to 1.7-1.9 mmol/L for 12-13 days by i.v. insulin infusion (n = 9, 121 days gestation, term = 150 days). Control ewes (n = 7) received vehicle. Maternal and fetal glucose concentrations were 40% and 31% lower than in controls (p < 0.001), respectively. Fetal plasma insulin levels fell 36% +/- 7% by day 7 (p < 0.05); IGF-I levels were unchanged. Arterial PO2 and pH increased and PCO2 fell (p < 0.05). Renal function was largely unaffected. Longitudinal growth was 28% slower and spleen weights were 36% smaller (p < 0.05); body and kidney weights were not affected. Renal renin levels and renin, angiotensinogen, and angiotensin receptor mRNA levels were similar to those of controls. Plasma renin levels increased from 2.1 +/- 0.6 to 7.6 +/- 2.8 ng angiotensin I.mL-1.h-1 (p = 0.01). Thus reductions in fetal glucose and insulin levels in late gestation that were sufficient to retard skeletal growth had no effect on kidney growth or function or the renal renin-angiotensin system, possibly because IGF-I levels were not reduced. There was, however, increased activity of the circulating renin-angiotensin system similar to that seen during insulin-induced hypoglycaemia.
机译：我们对妊娠晚期胎羊实施了持续减少的葡萄糖供应，以查看葡萄糖和胰岛素水平的降低是否影响肾脏的生长，肾素的表达和合成以及肾功能。静脉注射使孕妇的葡萄糖浓度在12-13天降低到1.7-1.9 mmol / L。胰岛素输注（n = 9，妊娠121天，足月= 150天）。母羊（n = 7）收到车辆。孕妇和胎儿的葡萄糖浓度分别比对照组低40％和31％（p <0.001）。到第7天，胎儿血浆胰岛素水平下降了36％+/- 7％（p <0.05）; IGF-1水平未改变。动脉PO2和pH升高，PCO2降低（p <0.05）。肾功能基本不受影响。纵向生长减慢28％，脾脏重量减慢36％（p <0.05）;身体和肾脏的重量没有受到影响。肾素水平，肾素，血管紧张素原和血管紧张素受体mRNA水平与对照组相似。血浆肾素水平从2.1 +/- 0.6升至7.6 +/- 2.8 ng血管紧张素I.mL-1.h-1（p = 0.01）。因此，足以延迟骨骼生长的妊娠后期胎儿葡萄糖和胰岛素水平的降低对肾脏的生长或功能或肾素-血管紧张素系统没有影响，可能是因为IGF-I水平并未降低。但是，循环中的肾素-血管紧张素系统的活性增加，与胰岛素诱导的低血糖期间相似。

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