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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic C57BL/6J mice before and after atorvastatin treatment.
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Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic C57BL/6J mice before and after atorvastatin treatment.

机译：阿托伐他汀治疗前后在正常胆固醇和高胆固醇C57BL / 6J小鼠中内皮糖蛋白的内皮表达。

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Endoglin (CD105) is a homodimeric transmembrane glycoprotein strongly related to transforming growth factor (TGF)-beta signaling and many pathological states. In this study, we wanted to evaluate whether endoglin is expressed in normocholesterolemic and hypercholesterolemic C57BL/6J mice as well as whether it is affected by atorvastatin treatment in these mice. C57BL/6J mice were fed with chow diet or an atherogenic diet for 12 weeks after weaning. In 2 atorvastatin-treated groups, mice were fed the same diets (chow or atherogenic) as described above except atorvastatin was added at the dosage of 10 mg x kg(-1) x day(-1) for the last 8 weeks before euthanasia. Biochemical analysis of blood samples revealed that administration of atherogenic diet significantly increased levels of total cholesterol, VLDL, LDL, and decreased levels of HDL. Atorvastatin treatment resulted in a significant decrease in total cholesterol and VLDL only in mice fed by atherogenic diet. Quantitative stereological analysis revealed that atorvastatin significantly decreased endothelial expression of endoglin in C57BL/6J mice fed the atherogenic diet. In conclusion, we demonstrated that endothelial expression of endoglin is upregulated by hypercholesterolemia and decreased by the hypolipidemic effect of atorvastatin in C57BL/6J mice, suggesting that endoglin expression could be involved in atherogenesis.
机译：内皮糖蛋白（CD105）是一种同型二聚跨膜糖蛋白，与转化生长因子（TGF）-β信号传导和许多病理状态密切相关。在这项研究中，我们想评估内皮糖蛋白是否在正常胆固醇和高胆固醇C57BL / 6J小鼠中表达，以及在这些小鼠中是否受到阿托伐他汀治疗的影响。断奶后，给C57BL / 6J小鼠喂以低脂饮食或致动脉粥样化饮食，持续12周。在2个阿托伐他汀治疗组中，给小鼠喂食与上述相同的饮食（ch咽或动脉粥样硬化），不同的是在安乐死前的最后8周以10 mg x kg（-1）x day（-1）的剂量添加阿托伐他汀。血液样本的生化分析表明，给予动脉粥样硬化饮食可显着增加总胆固醇，VLDL，LDL的水平，并降低HDL的水平。阿托伐他汀治疗仅在通过致动脉粥样化饮食喂养的小鼠中导致总胆固醇和VLDL的显着降低。定量的立体分析显示，阿托伐他汀可显着降低动脉粥样硬化饮食的C57BL / 6J小鼠内皮糖蛋白的内皮表达。总之，我们证明高胆固醇血症可导致内皮糖蛋白的内皮表达上调，而阿托伐他汀对C57BL / 6J小鼠的降血脂作用则可降低内皮糖蛋白的表达，这表明内皮糖蛋白的表达可能参与了动脉粥样硬化的形成。

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