...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Impact of alpha-lipoic acid on liver peroxisome proliferator-activated receptor-alpha, vascular remodeling, and oxidative stress in insulin-resistant rats.
【24h】

Impact of alpha-lipoic acid on liver peroxisome proliferator-activated receptor-alpha, vascular remodeling, and oxidative stress in insulin-resistant rats.

机译：α-硫辛酸对胰岛素抵抗大鼠肝过氧化物酶体增殖物激活的受体-α，血管重塑和氧化应激的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study sought to determine the impact of alpha-lipoic acid (LA) on superoxide anion (O(2)(*-)) production and peroxisome proliferator-activated receptor-alpha (PPARalpha) expression in liver tissue, plasma free fatty acids (FFA), and aortic remodeling in a rat model of insulin resistance. Sprague-Dawley rats (50-75 g) were given either tap water or a drinking solution containing 10% D-glucose for 14 weeks, combined with a diet with or without LA supplement. O(2)(*-) production was measured by lucigenin chemiluminescence, and PPAR-alpha expression by Western blotting. Cross-sectional area (CSA) of the aortic media and lumen and number of smooth muscle cells (SMC) were determined histologically. Glucose increased systolic blood pressure (SBP), plasma levels of glucose and insulin, and insulin resistance (HOMA index). All of these effects were attenuated by LA. Whereas glucose had no effect on liver PPAR-alpha protein level, it decreased plasma FFA. LA decreased the aortic and liver O(2)(*-) production, body weight, and plasma FFA levels in control and glucose-treated rats. Liver PPAR-alpha protein levels were increased by LA, and negatively correlated with plasma FFA. Medial CSA was reduced in all glucose-treated rats, and positively correlated with plasma FFA but not with SBP or aortic O(2)(*-) production. Glucose also reduced aortic lumen area, so that the media-to-lumen ratio remained unchanged. The ability of LA to lower plasma FFA appears to be mediated, in part, by increased hepatic PPAR-alpha expression, which may positively affect insulin resistance. Glucose-fed rats may serve as a unique model of aortic atrophic remodeling in hypertension and early metabolic syndrome.
机译：这项研究试图确定α-硫辛酸（LA）对肝脏组织中超氧阴离子（O（2）（*-））产生和过氧化物酶体增殖物激活的受体α（PPARalpha）表达，血浆游离脂肪酸（ FFA）和大鼠胰岛素抵抗模型中的主动脉重塑。给予Sprague-Dawley大鼠（50-75 g）自来水或含10％D-葡萄糖的饮用溶液，持续14周，并伴有或不伴有LA补充剂的饮食。 O（2）（*-）生产通过光泽精化学发光法测量，并通过蛋白质印迹法测定PPAR-α的表达。组织学测定主动脉和中腔的横截面积（CSA）和平滑肌细胞（SMC）的数量。葡萄糖增加收缩压（SBP），血浆葡萄糖和胰岛素水平以及胰岛素抵抗（HOMA指数）。所有这些作用都被洛杉矶削弱。葡萄糖对肝脏PPAR-α蛋白水平无影响，但可降低血浆FFA。 LA降低了对照组和葡萄糖治疗大鼠的主动脉和肝脏O（2）（*-）产量，体重和血浆FFA水平。肝PPAR-α蛋白水平升高，与血浆FFA呈负相关。在所有接受葡萄糖治疗的大鼠中，内侧CSA均降低，并且与血浆FFA正相关，但与SBP或主动脉O（2）（*-）生产没有正相关。葡萄糖还减少了主动脉腔面积，因此中腔比保持不变。 LA降低血浆FFA的能力似乎部分是由肝PPAR-α表达增加所介导的，这可能对胰岛素抵抗产生积极影响。葡萄糖喂养的大鼠可以作为高血压和早期代谢综合征中主动脉萎缩性重构的独特模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号