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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats.
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Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats.

机译：白藜芦醇消除了黏附分子并保护了TNBS诱导的大鼠溃疡性结肠炎。

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摘要

Resveratrol, a polyphenol compound with anti-inflammatory properties, has been previously evaluated for its beneficial effects in several ulcerative colitis models. However, the current study elucidates the effect of resveratrol on adhesion molecules, as well as its antioxidant efficacy in a trinitrobenzene sulfonic acid (TNBS)-induced ulcerative-colitis model. Colitis was induced by rectal instillation of TNBS, followed by daily per os administration of either sulphasalazine (300 mg/kg) or resveratrol (2 and 10 mg/kg) for 7 days. Administration of resveratrol decreased the ulcerative area and colon mass index; these effects were further supported by the reduction in colon inflammation grades, as well as histolopathological changes, and reflected by the stalling of body mass loss. The anti-inflammatory effects of resveratrol were indicated by lowered myeloperoxidase activity, and by suppressing ICAM-1 and VCAM-1 levels in the colon and serum. In addition, it restored a reduced colonic nitric oxide level and reinstated its redox balance, as evidenced by the suppression of lipid peroxides and prevention of glutathione depletion. The anti-ulcerative effect of the higher dose of resveratrol was comparable with those of sulphasalazine. The study confirms the anti-ulcerative effect of resveratrol in TNBS-induced experimental colitis via reduction of neutrophil infiltration, inhibition of adhesive molecules, and restoration of the nitric oxide level, as well as the redox status.
机译：白藜芦醇，一种具有抗炎特性的多酚化合物，先前已在几种溃疡性结肠炎模型中评估了其有益作用。但是，当前的研究阐明了白藜芦醇对粘附分子的影响，以及其在三硝基苯磺酸（TNBS）诱导的溃疡性结肠炎模型中的抗氧化功效。直肠滴注TNBS引起结肠炎，然后每天口服一次口服柳氮磺胺吡啶（300 mg / kg）或白藜芦醇（2和10 mg / kg）7天。白藜芦醇的使用减少了溃疡面积和结肠质量指数;结肠炎症等级的降低以及组织病理学改变进一步支持了这些作用，并且体重减轻的停滞反映了这些作用。白藜芦醇的抗炎作用通过降低髓过氧化物酶活性，并抑制结肠和血清中的ICAM-1和VCAM-1水平来表明。此外，它可以降低结肠中的一氧化氮水平，并恢复其氧化还原平衡，这可以通过抑制脂质过氧化物和防止谷胱甘肽耗竭来证明。高剂量白藜芦醇的抗溃疡作用与柳氮磺胺吡啶相当。该研究通过减少中性粒细胞浸润，抑制黏附分子，恢复一氧化氮水平以及氧化还原状态，证实了白藜芦醇在TNBS诱导的实验性结肠炎中具有抗溃疡作用。

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