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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Preliminary observations on high energy phosphates and metabolic pathway and transporter potentials in extensor carpi radialis brevis and trapezius muscles of women with work-related myalgia
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Preliminary observations on high energy phosphates and metabolic pathway and transporter potentials in extensor carpi radialis brevis and trapezius muscles of women with work-related myalgia

机译：与工作有关的肌痛女性的radial肌腕car短肌和斜方肌中高能磷酸盐和代谢途径及转运蛋白潜力的初步观察

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摘要

This study compared both the extensor carpi radialis brevis (ECRB) and the trapezius (TRAP) muscles of women with work-related myalgia (WRM) with healthy controls (CON) to determine whether abnormalities existed in cellular energy status and the potentials of the various metabolic pathways and segments involved in energy production and substrate transport. For both the ECRB (CON, n = 6-9; WRM, n = 13) and the TRAP (CON, n = 6-7; WRM, n = 10), no differences (P > 0.05) were found for the concentrations (in millimoles per kilogram of dry mass) of ATP, PCr, lactate, and glycogen. Similarly, with one exception, the maximal activities (in moles per milligram of protein per hour) of mitochondrial enzymes representative of the citric acid cycle (CAC), the electron transport chain (ETC), and beta-oxidation, as well as the cytosolic enzymes involved in high energy phosphate transfer, glycogenolysis, glycolysis, lactate oxidation, and glucose phosphorylation were not different (P > 0.05). The glucose transporters GLUT1 and GLUT4, and the monocarboxylate transporters MCT1 and MCT4, were also normal in WRM. It is concluded that, in general, abnormalities in the resting energy and substrate state, the potential of the different metabolic pathways and segments, as well as the glucose and monocarboxylate transporters do not appear to be involved in the cellular pathophysiology of WRM.
机译：这项研究比较了患有工作相关性肌痛（WRM）的女性的radial伸腕短肌（ECRB）和斜方肌（TRAP）肌肉与健康对照（CON）的关系，以确定细胞能量状态是否存在异常以及各种能量的潜力参与能量产生和底物转运的代谢途径和节段。对于ECRB（CON，n = 6-9; WRM，n = 13）和TRAP（CON，n = 6-7; WRM，n = 10），浓度没有差异（P> 0.05）。 ATP，PCr，乳酸和糖原（每千克干质量的单位为毫摩尔）。同样，除了一个例外，代表柠檬酸循环（CAC），电子传输链（ETC）和β-氧化以及细胞质的线粒体酶的最大活性（以每小时每毫克蛋白摩尔计）高能磷酸盐转移，糖原分解，糖酵解，乳酸氧化和葡萄糖磷酸化涉及的酶没有差异（P> 0.05）。葡萄糖转运蛋白GLUT1和GLUT4以及单羧酸盐转运蛋白MCT1和MCT4在WRM中也正常。结论是，一般而言，静止能量和底物状态异常，不同代谢途径和区段的潜力以及葡萄糖和单羧酸盐转运蛋白似乎与WRM的细胞病理生理无关。

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