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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Mechanisms increasing n-3 highly unsaturated fatty acids in the heart
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Mechanisms increasing n-3 highly unsaturated fatty acids in the heart

机译：增加心脏中n-3个高度不饱和脂肪酸的机制

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摘要

Due to ambiguous findings on cardiovascular benefits of systemic omega-3 fatty acid therapy, endogenous mechanisms contributing to local organ-specific concentrations of highly unsaturated fatty acids (HUFA) were examined. Using gas chromatography, 43 fatty acids were analyzed in atrial and ventricular myocardium and in pericardial fluid of male Wistar rats. To examine the endogenous fatty acid metabolism, precursors were administered into the pericardial sac. Pro-and anti-inflammatory actions were induced by talc or fenofibrate, respectively. Physical exercise and a sedentary obese state were used for increased beta-oxidation. DHA (22:6n-3) was increased in ventricular when compared with atrial myocardium (9.0 +/- 2.1% vs. 4.7 +/- 1.0%, p < 0.001). Intrapericardial EPA (20:5n-3) application lead to an increase of the succeeding tetracosapentaenoic acid (24:5n-3) in atrial myocardium, which is a key precursor of DHA. In contrast, proinflammatory stimulation of the n-6 HUFA pathway did not influence the n-3 metabolism. Exercise-and obesity-induced increased beta-oxidation, the finalizing step of DHA synthesis, was associated with increased ventricular DHA concentrations (6.7 +/- 1.0% vs. 8.4 +/- 1.2%, p < 0.01). It is concluded that the endogenous metabolism contributes markedly to myocardial HUFA concentrations. The findings are supposed to influence the efficacy of oral HUFA treatment and provide a rationale for divergent findings of previous trials on omega-3 therapy.
机译：由于关于全身性ω-3脂肪酸疗法对心血管的益处的模棱两可的发现，研究了导致局部器官特定浓度的高度不饱和脂肪酸（HUFA）的内源性机制。使用气相色谱法分析雄性Wistar大鼠的心房和心室心肌以及心包液中的43种脂肪酸。为了检查内源性脂肪酸代谢，将前体给药至心包囊中。滑石粉或非诺贝特分别诱导促炎和抗炎作用。体育锻炼和久坐的肥胖状态被用于增加β-氧化。与心房心肌相比，心室DHA（22：6n-3）升高（9.0 +/- 2.1％与4.7 +/- 1.0％，p <0.001）。心内膜EPA（20：5n-3）的应用导致心房心肌中随后的二十四碳五烯酸（24：5n-3）的增加，而心房心肌是DHA的重要前体。相反，n-6 HUFA途径的促炎性刺激不影响n-3代谢。运动和肥胖引起的β-氧化增加（DHA合成的最终步骤）与心室DHA浓度增加有关（6.7 +/- 1.0％对8.4 +/- 1.2％，p <0.01）。结论是内源性代谢显着影响心肌HUFA浓度。这些发现可能会影响口服HUFA治疗的疗效，并为先前有关omega-3治疗试验的不同发现提供理论依据。

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