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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Hypotensive, cardiodepressant, and vasorelaxant activities of black currant (Ribes nigrum 'Ben Sarek') juice
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Hypotensive, cardiodepressant, and vasorelaxant activities of black currant (Ribes nigrum 'Ben Sarek') juice

机译：黑加仑（Ribes nigrum'Ben Sarek'）果汁的降压，抗心律和血管舒张作用

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摘要

The aim of this study was to evaluate the effects of black currant (Ribes nigrum L. 'Ben Sarek') juice on the blood pressure and frequency of cardiac contractions, as well as vasomotor responses of rat aortic rings. Arterial blood pressure was measured directly from the carotid artery in the anaesthetized rabbits. The aortic rings were pre-contracted with KCl (80 mmol.L-1),after which black currant juice was added. An intravenous injection of black currant juice (0.33-166.5 mg.kg(-1)) induced a significant and dose-dependent decrease of rabbit arterial blood pressure and heart rate. The black currant juice decreased arterial blood pressure of rabbit by 22.33% +/- 3.76% (p < 0.05) and heart rate by 17.18% +/- 2.93% (p < 0.05). Cumulative addition of the black currant juice (0.01-3 mg.kg(-1)) inhibited concentration-dependent KCl induced contractions of the isolated rat aorta. The black currant juice, at the concentration of 3 mg.kg(-1), caused a maximum relaxation of 21.75% +/- 3.15% (p < 0.05). These results demonstrate that black currant juice can induce hypotension. The hypotensive effect of the black currant may occur as the consequence of its inhibitory activity on the rate of heart contraction and vasorelaxant effects.
机译：这项研究的目的是评估黑加仑（Ribes nigrum L.'Ben Sarek'）汁对血压和心脏收缩频率以及大鼠主动脉环血管舒缩反应的影响。直接从麻醉兔子的颈动脉中测量动脉血压。将主动脉环与KCl（80 mmol.L-1）预缩合，然后加入黑加仑汁。静脉注射黑加仑汁（0.33-166.5 mg.kg（-1））引起兔动脉血压和心率显着和剂量依赖性降低。黑加仑汁使兔子的动脉血压降低了22.33％+/- 3.76％（p <0.05），心率降低了17.18％+/- 2.93％（p <0.05）。黑加仑汁（0.01-3 mg.kg（-1））的累积添加抑制了浓度依赖性KCl诱导的离体大鼠主动脉收缩。黑加仑汁的浓度为3 mg.kg（-1），引起最大松弛度为21.75％+/- 3.15％（p <0.05）。这些结果证明黑加仑汁可以诱发低血压。黑加仑的降压作用可能是由于其对心脏收缩速率和血管舒张作用的抑制作用所致。

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