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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >High-fat diet differentially regulates metabolic parameters in obesity-resistant S5B/Pl rats and obesity-prone Osborne-Mendel rats
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High-fat diet differentially regulates metabolic parameters in obesity-resistant S5B/Pl rats and obesity-prone Osborne-Mendel rats

机译：高脂饮食在抗肥胖的S5B / Pl大鼠和易肥胖的Osborne-Mendel大鼠中差异调节代谢参数

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摘要

The current experiment tested the hypothesis that consumption of a high-fat diet (HFD) would differentially affect metabolic parameters in obesity-prone Osborne-Mendel (OM) and obesity-resistant S5B/Pl (S5B) rats. In OM rats consuming a HFD, an increase in HFD intake, body mass, and percent fat mass, and a HFD-induced decrease in metabolic rate and energy expenditure were demonstrated. In S5B rats consuming a HFD, no change in percent body fat or HFD intake was demonstrated and HFD increased metabolic rate and energy expenditure. To assess whether HFD differentially altered skeletal muscle markers of metabolism in OM and S5B rats, the expression of the transporters, CD36 and GLUT4, and the energy sensors, AMPK and PPAR gamma, in the gastrocnemius muscle was measured. Oxidation and lipid accumulation in the gastrocnemius muscle was histologically determined. Consumption of a HFD decreased phosphorylated AMPK and PPAR gamma expression in the skeletal muscle of obesity-prone OM rats. Lipid accumulation in skeletal muscle was significantly higher in OM rats fed a HFD. Overall, these data suggest that the differential response to HFD on metabolic rate, energy expenditure, and phosphorylated AMPK and PPAR gamma in OM and S5B rats, may partially account for differences in the susceptibility to develop obesity.
机译：当前的实验检验了以下假设：食用高脂饮食（HFD）将对易肥胖的Osborne-Mendel（OM）和抗肥胖的S5B / P1（S5B）大鼠的代谢参数产生不同的影响。在消耗HFD的OM大鼠中，证实了HFD摄入量，体重和脂肪含量的增加，以及HFD引起的代谢率和能量消耗的降低。在食用HFD的S5B大鼠中，没有发现人体脂肪百分比或HFD摄入量发生变化，并且HFD增加了代谢率和能量消耗。为了评估HFD是否在OM和S5B大鼠中差异地改变了骨骼肌代谢的标志物，测量了腓肠肌中转运蛋白CD36和GLUT4以及能量传感器AMPK和PPARγ的表达。组织学确定腓肠肌中的氧化和脂质蓄积。食用HFD可以降低易肥胖的OM大鼠骨骼肌的磷酸化AMPK和PPARγ表达。饲喂HFD的OM大鼠骨骼肌中的脂质蓄积明显更高。总体而言，这些数据表明，OM和S5B大鼠对HFD的代谢率，能量消耗以及磷酸化的AMPK和PPARγ的反应不同，可能部分解释了肥胖症易​​感性的差异。

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