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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury
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Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury

机译：铁和棕榈酸甲酯对乙酰氨基酚引起的急性肝损伤的细胞保护潜力

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摘要

Acute liver injury is a debilitating disorder associated with loss of synthetic and detoxifying functions of the liver. This investigation was designed to assess cytoprotective efficacy of daily oral tiron (300 mg/kg) and daily oral methyl palmitate (300 mg/kg) against acetaminophen-induced acute liver injury. Rats were orally pretreated with either tiron or methyl palmitate at doses (300 mg/kg) for 7 days prior to oral acetaminophen (3 g/kg). Biochemical assay of markers of hepatotoxicity indices and oxidative stress was undertaken. Expression of inflammatory cytokine IL-6 was also evaluated. Histopathological examination of liver specimens was carried out as well. Both methyl palmitate and tiron significantly reversed the acetaminophen-induced elevation of biochemical markers (ALT, AST, and ALP) with restoration of SOD levels. Serum albumin levels and GSH liver contents increased, but in a nonsignificant manner. Moreover, methyl palmitate and tiron significantly decreased the level of serum LDH and serum IL-6 levels. Histopathology revealed that tiron markedly reduced the extent of acetaminophen-induced necrosis and methyl palmitate moderately decreased the necrosis in liver tissue. Methyl palmitate (300 mg/kg) and tiron (300 mg/kg) demonstrated promising hepatoprotective effects against acetaminophen-induced acute liver injury via modulation of inflammatory response and alleviation of the oxidative stress, allowing the preservation of hepatic functions.
机译：急性肝损伤是与肝的合成和解毒功能丧失相关的衰弱性疾病。该研究旨在评估每日口服铁剂（300 mg / kg）和每日口服棕榈酸甲酯（300 mg / kg）对乙酰氨基酚引起的急性肝损伤的细胞保护作用。在口服对乙酰氨基酚（3 g / kg）之前，先以剂量（300 mg / kg）的替丁或棕榈酸甲酯对大鼠进行口服预处理7天。进行了肝毒性指标和氧化应激指标的生化分析。还评估了炎性细胞因子IL-6的表达。还进行了肝标本的组织病理学检查。棕榈酸甲酯和季铁均可显着逆转对乙酰氨基酚引起的生化指标（ALT，AST和ALP）升高，并能恢复SOD水平。血清白蛋白水平和谷胱甘肽肝含量增加，但无统计学意义。此外，棕榈酸甲酯和铁离子显着降低了血清LDH和IL-6的水平。组织病理学显示，铁剂显着减少了对乙酰氨基酚引起的坏死的程度，而棕榈酸甲酯则适度地减少了肝组织中的坏死。棕榈酸甲酯（300 mg / kg）和铁（300 mg / kg）通过调节炎症反应和减轻氧化应激表现出对乙酰氨基酚引起的急性肝损伤的有希望的肝保护作用，从而保留了肝功能。

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