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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study.
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Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study.

机译：γ射线全身照射后的血脑屏障通透性：一项体内微透析研究。

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摘要

The effects of total-body irradiation on the permeability of rat striatal blood-brain barrier (BBB) to [3H]alpha-aminoisobutyric acid (AIBA) and [14C]sucrose were investigated using the microdialysis technique. Seven days, 3 and 6 weeks, and 3, 5, and 8 months after gamma exposure at a dose of 4.5 Gy, no modification of the permeability to both [3H]AIBA and [14C]sucrose was observed. But, in the course of the initial syndrome, we observed a significant but transient increase in the BBB permeability to the two markers between 3 and 17 h after exposure. A secondary transient opening irradiation without the corresponding increase in BBB permeability to [3H]AIBA. On the contrary, the transport of [3H]AIBA through the BBB was decreased between 33 and 47 h postradiation. In conclusion, our experiments showed early modifications of BBB permeability after a moderate-dose whole-body exposure. Confirmation of these results with other tracers, in another experimental model or in humans, would have clinical applications for designing appropriate pharmacotherapy in radiotherapy and treatment of accidental overexposure.
机译：使用微透析技术研究了全身照射对大鼠纹状体血脑屏障（BBB）对[3H]α-氨基异丁酸（AIBA）和[14C]蔗糖通透性的影响。在以4.5 Gy的剂量接触伽马射线后7天，3周和6周以及3、5和8个月，未观察到对[3H] AIBA和[14C]蔗糖的渗透性发生任何改变。但是，在最初的综合症过程中，我们观察到暴露后3至17小时之间，BBB对这两种标记物的通透性显着但短暂的增加。次生暂时性开放照射，但对[3H] AIBA的血脑屏障通透性没有相应增加。相反，[3H] AIBA通过BBB的转运在放疗后33至47小时之间减少。总之，我们的实验表明，中等剂量的全身暴露后BBB通透性的早期改变。在其他实验模型或人类中，用其他示踪剂确认这些结果将具有临床应用，可用于设计放射治疗和意外过度暴露的适当药物治疗。

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