首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Methods to measure the cutaneous transfer of radionuclides across the intact or lesioned epidermis, application to radiotoxicology
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Methods to measure the cutaneous transfer of radionuclides across the intact or lesioned epidermis, application to radiotoxicology

机译:测量放射性核素在完整表皮或病变表皮上的皮肤转移的方法,在放射毒理学中的应用

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摘要

Although skin contamination by radionuclides is the most common cause of nuclear workers accidents, few studies dealing with the penetration of radioactive contamination through the skin are available. This work is a review of experimental methods that allow to assess transfer of radionuclides through the skin in occupational conditions, with or without skin trauma. The first section describes the different methods applied for skin transfer assessment of chemicals used in pharmacology. Major radionuclide contamination accidents can be associated with skin traumas. Thus, the second section describes the adaptation of these methods to radiotoxicology. Finally, the third section is an in vivo investigation of cobalt transfer (57CoCl2) through undamaged and damaged skin which simulates different industrial accident conditions (excoriation, acid or alcalin burn, scalding, branding).
机译:尽管放射性核素引起的皮肤污染是核工作人员事故的最常见原因,但很少有研究涉及放射性污染物通过皮肤的渗透。这项工作是对实验方法的回顾,该方法可以评估在有或没有皮肤创伤的情况下,放射性核素在皮肤中通过皮肤的转移。第一部分描述了用于药理学中化学物质皮肤转移评估的不同方法。重大的放射性核素污染事故可能与皮肤创伤有关。因此,第二部分描述了这些方法对放射毒理学的适应性。最后,第三部分是体内对未损伤和受损皮肤的钴转移(57CoCl2)的体内研究,该过程模拟了不同的工业事故情况(剥落,酸或alcalin灼伤,烫伤,烙印)。

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