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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effect of pre-exposure to beta rays of tritium on some biochemical parameters measured in organs of rats subsequently irradiated with fast neutrons.
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Effect of pre-exposure to beta rays of tritium on some biochemical parameters measured in organs of rats subsequently irradiated with fast neutrons.

机译：预先暴露于beta的β射线对随后用快中子辐照的大鼠器官中测得的某些生化参数的影响。

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The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre-contaminated to 7 cGy and 35 cGy have been additionally irradiated to 1 Gy with fast neutrons. Lipid peroxide level was determined in liver, kidney, small intestine, spleen, bone marrow, and plasma. Reduced glutathione (GSH) level and glucose-6-phosphate dehydrogenase (G6PDH) activity were determined in erythrocytes. An in vitro thymidine uptake assay was performed in isolated bone marrow cells. The lipid peroxide level decreased significantly only in liver and kidney from rats pre-exposed to 35 cGy. For small intestine and spleen, tissues of comparatively higher radiosensitivity, no induced radioprotection was observed, as reflected in the homeostasis of the lipid peroxides. The same behavior was observed in bone marrow, the most radiosensitive tissue studied. However, the bone marrow thymidine-incorporation assay revealed a possible adaptive-type reaction in rats pre-exposed to 35 cGy. We conclude that for radiosensitive tissues pre-exposure to chronic low doses of low linear energy transfer (LET) irradiation has no protective effect on their antioxidant status, whereas a protective effect is observed in radioresistent tissues.
机译：该实验研究了先后顺序接触低浓度tri污染，然后用快速中子进行挑战性照射而产生的生物学反应。讨论了与组织放射敏感性有关的大鼠不同器官内源性抗氧化能力的改变。预先污染了7 cGy和35 cGy的大鼠还用快中子辐照到1 Gy。测定肝脏，肾脏，小肠，脾脏，骨髓和血浆中的脂质过氧化物水平。确定了减少的谷胱甘肽（GSH）水平和葡萄糖6磷酸脱氢酶（G6PDH）活性。在分离的骨髓细胞中进行了体外胸苷吸收测定。脂质过氧化物水平仅在预先暴露于35 cGy的大鼠的肝脏和肾脏中显着降低。对于小肠和脾脏，放射敏感性较高的组织没有观察到诱导的放射防护，这反映在脂质过氧化物的体内稳态中。在研究的最放射敏感性组织骨髓中也观察到了相同的行为。但是，骨髓胸腺嘧啶核苷掺入试验显示，在预先暴露于35 cGy的大鼠中可能存在适应性反应。我们得出的结论是，对于放射敏感性组织，预先暴露于慢性低剂量的低线性能量转移（LET）辐射对它们的抗氧化剂状态没有保护作用，而在抗辐射组织中观察到了保护作用。

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