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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Cardiovascular effects of 1,8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats.
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Cardiovascular effects of 1,8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats.

机译：1,8-桉树脑（一种存在于许多植物精油中的萜类氧化物）对血压正常的大鼠的心血管作用。

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The cardiovascular effects of i.v. treatment with 1,8-cineole, a monoterpenic oxide present in many plant essential oils, were investigated in normotensive rats. This study examined (i) whether the autonomic nervous system is involved in the mediation of 1,8-cineole-induced changes in mean aortic pressure (MAP) and heart rate (HR) and (ii) whether the hypotensive effects of 1,8-cineole could result from its vasodilatory effects directly upon vascular smooth muscle. In both pentobarbital-anesthetized and conscious, freely moving rats, bolus injections of 1,8-cineole (0.3-10 mg/kg, i.v.) elicited similar and dose-dependent decreases in MAP. Concomitantly, 1,8-cineole significantly decreased HR only at the highest dose (10 mg/kg). Pretreatment of anesthetized rats with bilateral vagotomy significantly reduced the bradycardic responses to 1,8-cineole (10 mg/kg) without affecting hypotension. In conscious rats, i.v. pretreatment with methylatropine (1 mg/kg), atenolol (1.5 mg/kg), or hexamethonium (30 mg/kg) had no significant effects on the 1,8-cineole-induced hypotension, while bradycardic responses to 1,8-cineole (10 mg/kg) were significantly reduced by methylatropine. In rat isolated thoracic aorta preparations, 1,8-cineole (0.006-2.6 mM) induced a concentration-dependent reduction of the contraction induced by potassium (60 mM). This is the first physiological evidence that i.v. treatment with 1,8-cineole in either anesthetized or conscious rats elicits hypotension; this effect seems related to an active vascular relaxation rather than withdrawal of sympathetic tone.
机译：i.v.的心血管作用在血压正常的大鼠中研究了1,8-桉树脑（一种存在于许多植物精油中的单萜类氧化物）的治疗方法。这项研究检查（i）是否自主神经系统参与了1,8-桉树脑诱导的平均主动脉压（MAP）和心率（HR）的变化，以及（ii）1,8的降压作用-cineole可能直接来自其对血管平滑肌的血管舒张作用。在戊巴比妥麻醉的和有意识的自由运动大鼠中，推注1,8-桉树脑（0.3-10 mg / kg，静脉内）可引起MAP的相似且剂量依赖性的降低。同时，仅在最高剂量（10 mg / kg）下，1,8-桉树脑才能显着降低心率。麻醉大鼠的双侧迷走神经切断术可显着降低对1,8-桉树脑（10 mg / kg）的心动过缓反应，而不会影响低血压。在有意识的大鼠中，静脉注射用甲基阿托品（1 mg / kg），阿替洛尔（1.5 mg / kg）或六甲铵（30 mg / kg）预处理对1,8-桉树脑诱导的低血压无明显影响，而对1,8-桉树脑的心动过缓反应（10 mg / kg）被甲基阿托品显着降低。在大鼠分离的胸主动脉制剂中，1,8-桉树脑（0.006-2.6 mM）诱导了钾（60 mM）诱导的收缩的浓度依赖性降低。这是i.v.在麻醉或清醒大鼠中用1,8-桉树脑治疗会引起低血压;这种作用似乎与主动血管舒张有关，而不是交感神经退缩。

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