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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Vitamin C lowers blood pressure and alters vascular responsiveness in salt-induced hypertension.
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Vitamin C lowers blood pressure and alters vascular responsiveness in salt-induced hypertension.

机译：维生素C可以降低盐引起的高血压并改变血管反应性。

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摘要

The present study was undertaken to investigate the effect of vitamin C treatment on blood pressure and vascular reactivity in salt-induced hypertension. Male Sprague-Dawley rats were fed a normal rat diet, a high-sodium (8% NaCl) diet, a normal rat diet plus vitamin C treament (100 mg x kg(-1) x day(-1)), or a high-sodium diet plus vitamin C treatment for 6 weeks. Salt loading significantly increased blood pressure, which was attenuated by vitamin C treatment. Aortic rings from the different groups were suspended for isometric-tension recording. The contractile response to noradrenaline was significantly increased in the salt-loaded rats. Vitamin C reduced the sensitivity of aortic rings to noradrenaline in rats on normal and high-sodium diets. In noradrenaline-precontracted rings, the relaxation response to acetylcholine, which was attenuated in the salt-loaded rats, was restored by vitamin C treatment. Pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME) abolished the enhanced response to acetylcholine caused by vitamin C. The results suggest that the antihypertensive effect of vitamin C is associated with a reduction in vascular sensitivity to noradrenaline and enhancement of endothelium-dependent relaxation due to increased nitric oxide bioavailability.
机译：本研究旨在探讨维生素C治疗对盐引起的高血压患者血压和血管反应性的影响。给雄性Sprague-Dawley大鼠喂食正常大鼠饮食，高钠（8％NaCl）饮食，正常大鼠饮食加维生素C治疗（100 mg x kg（-1）x day（-1））或高钠饮食加维生素C治疗6周。盐负荷显着增加了血压，而维生素C处理则降低了血压。悬挂来自不同组的主动脉环以记录等轴测张力。盐负荷大鼠对去甲肾上腺素的收缩反应显着增加。在正常和高钠饮食下，维生素C降低了大鼠主动脉环对去甲肾上腺素的敏感性。在去甲肾上腺素预收缩的环中，通过维生素C处理可恢复对盐负荷大鼠减弱的对乙酰胆碱的松弛反应。用N（G）-硝基-L-精氨酸甲酯（L-NAME）进行的预处理消除了维生素C对乙酰胆碱的增强反应。结果表明，维生素C的降压作用与降低血管对去甲肾上腺素的敏感性有关一氧化氮的生物利用度增加引起内皮依赖性松弛的增强。

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