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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Pancreatic islet transplantation, but not intensive insulin therapy, corrects the pulmonary vascular complications of streptozotocin diabetes.
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Pancreatic islet transplantation, but not intensive insulin therapy, corrects the pulmonary vascular complications of streptozotocin diabetes.

机译：胰岛移植而非强化胰岛素治疗可纠正链脲佐菌素糖尿病的肺血管并发症。

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We examined the effects of long-term streptozotocin (STZ) diabetes and its treatment by intensive insulin therapy (IIT) or pancreatic islet transplantation on pulmonary pressor and depressor responses and segmental resistance profiles in female Wistar-Furth rats. Pulmonary vascular reactivity was examined using isolated, salt-perfused lungs at a constant flow rate of 30 mL.min-1.kg-1 body weight. Baseline perfusion pressure was significantly (p < 0.05) lower in lungs obtained from IIT animals compared with all other treatment groups. Following STZ administration, pressor responsiveness to 1.0 microgram of U-46619 (9,11-dideoxy-9 alpha, 11 alpha-methanoepoxy prostaglandin F2 alpha) was decreased in diabetic compared with IIT animals (9.33 +/- 0.54 vs. 11.94 +/- 0.29 mmHg (1 mmHg = 133.3 Pa)). Diabetes caused a similar decrease in the vasodilatory response to arginine vasopressin when compared with IIT animals (39.25 +/- 7.54 vs. 68.24 +/- 4.75%). Diabetes was also associated with a shift in the primary site of resistance from the pulmonary arterial to the pulmonary venous bed. This shift was restored to normal following pancreatic islet transplantation, but not IIT. IIT was also associated with significant alterations in the pattern of constrictor and dilator responses to U-46619 and arginine vasopressin. Pulmonary venous vasoconstrictor responses to U-46619 were augmented when compared with either control or diabetic animals, but not transplant. In addition, pulmonary venous vasoconstrictor responses in IIT animals were significantly greater than pulmonary arterial responses in the same group, a finding that was unique to IIT animals. Finally, IIT significantly augmented the pulmonary venous vasodilatory response to arginine vasopressin when compared with all other treatment groups. These data demonstrate significant alterations in pulmonary hemodynamic status of STZ diabetic female animals and suggest that pancreatic islet transplantation may be more beneficial than intensive insulin therapy in ameliorating these changes.
机译：我们检查了长期链脲佐菌素（STZ）糖尿病的影响及其通过强化胰岛素治疗（IIT）或胰岛移植治疗对雌性Wistar-Furth大鼠的肺升压和降压反应以及节段性抵抗的影响。使用分离的盐灌注肺，以30 mL.min-1.kg-1体重的恒定流速检查肺血管反应性。与所有其他治疗组相比，从IIT动物获得的肺部基线灌注压显着降低（p <0.05）。与IIT动物相比，STZ给药后，糖尿病患者对1.0微克U-46619（9,11-二脱氧-9α，11α-甲氧基环氧前列腺素F2α）的升压反应性降低（9.33 +/- 0.54对11.94 + / -0.29毫米汞柱（1毫米汞柱= 133.3 Pa））。与IIT动物相比，糖尿病引起的对精氨酸加压素血管舒张反应的相似降低（39.25 +/- 7.54对68.24 +/- 4.75％）。糖尿病还与耐药的主要部位从肺动脉向肺静脉床的转移有关。胰岛移植后，这种转变恢复了正常，但IIT没有恢复。 IIT还与对U-46619和精氨酸加压素的收缩和扩张反应模式的重大改变有关。与对照组或糖尿病动物相比，对U-46619的肺静脉血管收缩反应增强，但不移植。此外，IIT动物中的肺静脉血管收缩反应明显高于同一组中的肺动脉反应，这一发现是IIT动物所独有的。最后，与所有其他治疗组相比，IIT显着增强了对精氨酸加压素的肺静脉血管舒张反应。这些数据表明，STZ糖尿病雌性动物的肺血流动力学状态发生了显着变化，并表明胰岛移植在改善这些变化方面可能比强化胰岛素治疗更为有益。

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