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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Renal effect of meloxicam versus ketoprofen in anaesthetized pseudo-normovolaemic piglets.
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Renal effect of meloxicam versus ketoprofen in anaesthetized pseudo-normovolaemic piglets.

机译：美洛昔康与酮洛芬在麻醉的伪降血型仔猪中的肾脏作用。

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摘要

Due to renal COX-2 constitutive expression, meloxicam is presumably deleterious for kidney function in critical situations. The present study investigates the influence of intravenous meloxicam on renal parameters and compares it with a nonselective COX inhibitor, ketoprofen. Piglets (n = 6 in each group) were treated with ketoprofen (2 mg.kg-1), meloxicam (0.2 mg.kg-1), or saline at the beginning of anaesthesia. Under intravenous anaesthesia, pigs were instrumented for cardiovascular, respiratory, and renal function evaluation, including urinary flow (UF), glomerular filtration rate (GFR), and renal blood flow (RBF). After baseline data collection (U0), data collection consisted of six 20-minute periods (U1 to U6). In all groups, the time course of cardiovascular and respiratory parameters remained within normal ranges. A small decrease in cardiac output and an increase in mean systemic arterial blood pressure (p = 0.002) occurred in all groups. In the placebo group, a similar decrease was observed for RBF and cardiac output, with troughs of -10.1% +/- 6.8%, and -12.9% +/- 3.2%, respectively. GFR and UF, however, remained stable over time in this group. Ketoprofen significantly decreased UF (-29.3% +/- 5.5% max at U3), with similar decreases in GFR and RBF. Meloxicam induced a transient (at U2) and small decrease in UF with no difference, at any time point, with the placebo group. The renal effects of meloxicam appear minimal and transient in anaesthetized piglets. This study demonstrates the safety of meloxicam for preemptive surgical analgesia under conditions of normovolaemia. Fluid therapy appears recommended to prevent any renal dysfunction.
机译：由于肾脏COX-2的组成型表达，美洛昔康在危急情况下可能对肾脏功能有害。本研究调查了静脉注射美洛昔康对肾脏参数的影响，并将其与非选择性COX抑制剂酮洛芬进行了比较。麻醉开始时，用酮洛芬（2 mg.kg-1），美洛昔康（0.2 mg.kg-1）或生理盐水治疗小猪（每组6只）。在静脉麻醉下，对猪进行心血管，呼吸和肾功能评估，包括尿流量（UF），肾小球滤过率（GFR）和肾血流量（RBF）。基线数据收集（U0）之后，数据收集包括六个20分钟的时间段（U1至U6）。在所有组中，心血管和呼吸参数的时程都保持在正常范围内。在所有组中，心输出量都有小幅下降，平均全身动脉血压升高（p = 0.002）。在安慰剂组中，RBF和心输出量也有类似的下降，谷值分别为-10.1％+/- 6.8％和-12.9％+/- 3.2％。然而，随着时间的推移，该组的GFR和UF保持稳定。酮洛芬显着降低了UF（U3时最大-29.3％+/- 5.5％），而GFR和RBF下降相似。美洛昔康诱导了短暂的（U2）和UF的小幅下降，在任何时间点上与安慰剂组无差异。在麻醉的仔猪中，美洛昔康对肾脏的影响极小且短暂。这项研究证明了美洛昔康在降血钙症条件下进行先发性手术镇痛的安全性。似乎建议使用液体疗法以预防任何肾功能不全。

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