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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Neuropeptide Y stimulates DNA synthesis in human vascular smooth muscle cells through neuropeptide Y Y1 receptors.
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Neuropeptide Y stimulates DNA synthesis in human vascular smooth muscle cells through neuropeptide Y Y1 receptors.

机译：神经肽Y通过神经肽Y Y1受体刺激人血管平滑肌细胞中的DNA合成。

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摘要

We investigated the mitogenic effect, measured as [3H]thymidine incorporation, of neuropeptide Y (NPY) on smooth muscle cells (SMCs) from human subcutaneous arteries (diameter: 0.4 mm). NPY stimulated DNA synthesis in a concentration-dependent manner, Emax 32 +/- 5% relative to control. The effect was potently antagonised by the NPY Y1 receptor antagonist BIBP3226 ((R)-N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine-a mide), indicating the effect to be mediated via the NPY Y1 receptor. Noradrenaline (NA) also induced mitogenesis, Emax 35 +/- 10% relative to control. When added together, NPY and NA potentiated the [3H]thymidine incorporation, Emax 109 +/- 38% relative to control. Also, this effect seems to be mediated by the NPY Y1 receptor, since BIBP3226 blocked the effect (44 +/- 9% relative to control). The mitogenic effect of NPY and NA, two important transmitters of the sympathetic nervous system, might have clinical consequences on conditions with elevated sympathetic nerve activity.
机译：我们研究了神经肽Y（NPY）对人皮下动脉（直径：0.4 mm）平滑肌细胞（SMC）的促有丝分裂作用，以[3H]胸苷掺入量衡量。 NPY以浓度依赖性方式刺激DNA合成，相对于对照，Emax为32 +/- 5％。 NPY Y1受体拮抗剂BIBP3226（（R）-N2-（二苯基乙酰基）-N-[（4-羟基-苯基）甲基] -D-精氨酸-a mide）强力拮抗了该作用，表明该作用已被介导通过NPY Y1受体。去甲肾上腺素（NA）也诱导有丝分裂发生，相对于对照，Emax为35 +/- 10％。当一起添加时，NPY和NA增强了[3 H]胸苷的掺入，相对于对照，Emax为109 +/- 38％。而且，该作用似乎由NPY Y1受体介导，因为BIBP3226阻断了该作用（相对于对照为44 +/- 9％）。交感神经系统的两个重要递质NPY和NA的促有丝分裂作用可能在交感神经活性升高的情况下产生临床后果。

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