Attrition in the drug discovery process: Lessons to be learned from the safety pharmacology paradigm

CurtisM.J.; PugsleyM.K.

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Attrition in the drug discovery process: Lessons to be learned from the safety pharmacology paradigm

机译：药物发现过程中的消耗：从安全药理学范例中吸取的教训

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A paradox in pharmacology has evolved over the last 10-15 years. Although competition in discovery has failed to deliver a sufficient flow of new medicines to sustain the viability of many companies within the pharmaceutical industry, cooperation between pharmaceutical companies has allowed safety pharmacology to mature into a coherent, efficient discipline. Separately, academia has moved increasingly away from understanding drugs into the world of intracellular signal processing and pathway mapping, with grant income and publication outcome the arbiters of academic success. This article poses these questions: what can discovery science learn from safety pharmacology that may be applied in order to begin to 'refill the pipelines' and what role may academia play in this process?

机译：在过去的10到15年中，药理学中的一个悖论得到了发展。尽管发现竞争未能提供足够的新药来维持制药业中许多公司的生存能力，但制药公司之间的合作已使安全药理学发展成为一个连贯，高效的学科。另外，学术界已逐渐从对药物的了解转移到细胞内信号处理和途径作图的世界，补助金收入和发表成果成为学术成功的仲裁者。本文提出了以下问题：发现科学可以从安全药理学中学到什么，这些安全药理学可以用来开始“补充管线”，而学术界在此过程中可能起什么作用？

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《Expert review of clinical pharmacology》 |2012年第3期|共4页
作者
CurtisM.J.; PugsleyM.K.;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
academia; cardiac toxicity; discovery pharmacology; drug attrition; drug development costs; intellectual property; safety pharmacology;

机译：学术界;心脏毒性;发现药理学;药物消耗;药物开发成本;知识产权;安全药理学;

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1. Attrition in the drug discovery process: Lessons to be learned from the safety pharmacology paradigm [J] . CurtisM.J., PugsleyM.K. Expert review of clinical pharmacology . 2012,第3期

机译：药物发现过程中的消耗：从安全药理学范例中吸取的教训
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Attrition in the drug discovery process: Lessons to be learned from the safety pharmacology paradigm

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