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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Bidirectional communication between the pineal gland and the immune system.
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Bidirectional communication between the pineal gland and the immune system.

机译：松果体与免疫系统之间的双向通讯。

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摘要

The pineal gland is a vertebrate neuroendocrine organ converting environmental photoperiodic information into a biochemical message (melatonin) that subsequently regulates the activity of numerous target tissues after its release into the bloodstream. A phylogenetically conserved feature is increased melatonin synthesis during darkness, even though there are differences between mammals and birds in the regulation of rhythmic pinealocyte function. Membrane-bound melatonin receptors are found in many peripheral organs, including lymphoid glands and immune cells, from which melatonin receptor genes have been characterized and cloned. The expression of melatonin receptor genes within the immune system shows species and organ specificity. The pineal gland, via the rhythmical synthesis and release of melatonin, influences the development and function of the immune system, although the postreceptor signal transduction system is poorly understood. Circulating messages produced by activated immune cells are reciprocally perceived by the pineal gland and provide feedback for the regulation of pineal function. The pineal gland and the immune system are, therefore, reciprocally linked by bidirectional communication.
机译：松果体是脊椎动物的神经内分泌器官，将环境光周期信息转换为生化信息（褪黑激素），该信息随后在释放到血流中后调节许多靶组织的活性。即使在哺乳动物和鸟类在节律性松果体细胞功能的调节方面存在差异，系统发育上保守的特征是在黑暗中褪黑激素合成增加。膜结合的褪黑激素受体存在于许多外周器官中，包括淋巴腺和免疫细胞，从中已经鉴定并克隆了褪黑激素受体基因。褪黑激素受体基因在免疫系统中的表达显示出物种和器官特异性。松果体通过褪黑激素的节律性合成和释放，影响了免疫系统的发育和功能，尽管对受体后信号转导系统的了解很少。松果体相互感知由活化的免疫细胞产生的循环信息，并为调节松果体功能提供反馈。因此，松果体和免疫系统通过双向通讯相互连接。

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