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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Possible role of nicaraven in neuroprotective effect on hippocampal slice culture.
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Possible role of nicaraven in neuroprotective effect on hippocampal slice culture.

机译：尼卡文对海马切片培养物神经保护作用的可能作用。

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摘要

Nicaraven is an agent that is especially beneficial in vasospasm or brain damage caused by subarachnoid hemorrhage. It ameliorates neurological deficits of patients and protects the central nervous system from ischemia. We investigated the neuroprotective effect of nicaraven against oxygen-glucose deprivation (OGD) induced or N-methyl-D-aspartic acid (NMDA) induced hippocampal neuronal cell death in organotypic brain slice cultures. The effect of nicaraven on hippocampal neuronal injury was evaluated by inhibition of uptake of propidium iodide (PI) into dead cells. The results demonstrated that nicaraven protected neuronal cells from both OGD- and NMDA-induced cell death. While nicaraven has a strong hydroxyl radical scavenging effect, another radical scavenger, N-acetyl-L-cysteine (NAC), inhibited cell death only caused by OGD. In contrast, the poly(ADP-ribose) synthetase (PARS) inhibitors 3-aminobenzamide (3-AB) and theophylline protected cells from both OGD- and NMDA-induced cell death. Since nicaraven has an inhibitory effect in PARS, as well as a radical scavenging effect, these results suggest that inhibition of hippocampal cell death caused by NMDA may be attributable to PARS inhibition by nicaraven.
机译：Nicaraven是对蛛网膜下腔出血引起的血管痉挛或脑损伤特别有益的药物。它改善了患者的神经功能缺损，并保护了中枢神经系统免于局部缺血。我们调查了烟碱对器官型脑切片培养物中氧-葡萄糖剥夺（OGD）诱导或N-甲基-D-天冬氨酸（NMDA）诱导的海马神经元细胞死亡的神经保护作用。尼卡文对海马神经元损伤的作用通过抑制碘化丙啶（PI）摄入死细胞中来评估。结果表明，尼古拉文可以保护神经元细胞免受OGD和NMDA诱导的细胞死亡。尽管尼加拉文具有很强的清除羟自由基的作用，但另一种自由基清除剂N-乙酰基-L-半胱氨酸（NAC）抑制仅由OGD引起的细胞死亡。相比之下，聚（ADP-核糖）合成酶（PARS）抑制剂3-氨基苯甲酰胺（3-AB）和茶碱可保护细胞免受OGD和NMDA诱导的细胞死亡。由于尼卡芬对PARS具有抑制作用以及清除自由基的作用，因此这些结果表明，抑制NMDA引起的海马细胞死亡可能归因于尼卡芬对PARS的抑制作用。

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