The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years

Pekarsky Yuri; Drusco Alessandra; Kumchala Prasanthi; Croce Carlo M.; Zanesi Nicola

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The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years

机译：TCL1转基因小鼠的漫长旅程：最近15年的经验教训

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The first transgenic mouse of the TCL1 oncogene was described more than 15 years ago, and since then, the overexpression of the gene in T- and B-cells in vivo has been extensively studied to reveal the molecular details in the pathogenesis of some lymphocytic leukemias. This review discusses the main features of the original TCL1 models and the different lines of research successively developed with particular attention to genetically compound mice and the therapeutic applications in drug development.

机译：TCL1致癌基因的第一只转基因小鼠已有15多年的历史，从那时起，对该基因在体内T细胞和B细胞中的过表达进行了广泛研究，以揭示某些淋巴细胞性白血病发病机理的分子细节。。这篇综述讨论了原始TCL1模型的主要特征以及相继发展的不同研究领域，尤其关注遗传复合小鼠及其在药物开发中的治疗应用。

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来源
《Gene expression》 |2015年第3期|共7页
作者
Pekarsky Yuri; Drusco Alessandra; Kumchala Prasanthi; Croce Carlo M.; Zanesi Nicola;
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原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词
Lck-TCL1; B-Cell; E mu-TCL1; Chronic lymphocytic leukemia (CLL); Mouse models;

机译：Lck-TCL1;B细胞;E mu-TCL1;慢性淋巴细胞性白血病（CLL）;小鼠模型;

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1. The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years [J] . Pekarsky Yuri, Drusco Alessandra, Kumchala Prasanthi, Gene expression . 2015,第3期

机译：TCL1转基因小鼠的漫长旅程：最近15年的经验教训
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6. The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years [O] . Yuri Pekarsky, Alessandra Drusco, Prasanthi Kumchala, -1

机译：TCL1转基因小鼠的漫长旅程：过去15年的经验教训
7. The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years [O] . Yuri Pekarsky, Alessandra Drusco, Prasanthi Kumchala, 2015

机译：Tcl1 转基因小鼠的长途旅程：在过去的15年里学到的经验教训

The Long Journey of TCL1 Transgenic Mice: Lessons Learned in the Last 15 Years

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