• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gene expression >Single Nucleotide Polymorphisms in HIF-1 alpha Gene and Residual Ridge Resorption (RRR) of Mandible in Korean Population
【24h】

Single Nucleotide Polymorphisms in HIF-1 alpha Gene and Residual Ridge Resorption (RRR) of Mandible in Korean Population

机译：HIF-1 alpha基因中的单核苷酸多态性和韩国人群下颌骨的残留脊突吸收（RRR）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tooth extraction is a routine surgical procedure in dental treatment. As a wound healing process after tooth extraction, a saddle-shaped residual ridge forms due to bone formation in the extraction socket and localized bone resorption on the external surface of the jawbone. The residual ridge is subjected to continuous bone resorption with substantial differences among individuals. In some cases, it results in excessive bone atrophy, which complicates dental restorative treatment. This unique oral wound healing process may be influenced by factors that are specific to oral tissue. HIF expression is different in oral wound healing compared to that of skin wounds. The objective of this study was to examine a genetic association between SNP of the HIF-1 alpha gene, which is known to have high genetic diversity, and the residual ridge resorption (RRR). Two hundred and two Korean subjects (70.80 +/- 9.40 years) with partially or completely edentulous mandible were recruited, and edentulous mandibular bone height was measured following the protocol of the American College of Prosthodontists. The HIF-1 alpha allele was directly sequenced in 24 subjects resulting in the variants over 5% frequency in 95% likelihood, whereas tag-SNPs were selected to perform analysis for the remaining population. Student's t-test and ANOVA were used for statistical analysis to examine the association between the SNPs and the RRR. Four novel variants were discovered, and a minor allele of rs11549467 was associated with the RRR of the subjects (p = 0.028). rs11549467 increases HIF-1 alpha transactivity, enhancing angiogenesis and increasing new vessel formation. Thus, rs11549467 may play an important role in the disturbed bone remodeling balance resulting in RRR. Results of this study may be useful in developing novel genetic diagnostic tests and identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction. Most importantly, early screening using genetic information will rescue susceptible patients from the vulnerable situation of excessive jawbone atrophy where no effective prosthetic treatment is available.
机译：拔牙是牙科治疗中的常规外科手术。作为拔牙后的伤口愈合过程，由于拔牙窝中的骨形成以及颌骨外表面上的局部骨吸收，形成了鞍形残留脊。残留的脊骨要经过连续的骨吸收，个体之间存在实质性差异。在某些情况下，它会导致骨质萎缩过度，这使牙齿修复治疗变得复杂。这种独特的口腔伤口愈合过程可能受口腔组织特有因素的影响。与皮肤伤口相比，口腔伤口愈合中的HIF表达有所不同。这项研究的目的是检查已知具有高遗传多样性的HIF-1 alpha基因的SNP与残留的脊骨吸收（RRR）之间的遗传关联。招募了202名具有部分或完全无牙颌的韩国受试者（70.80 +/- 9.40岁），并按照美国修复牙齿学会的协议测量了无牙颌骨的高度。 HIF-1α等位基因直接在24位受试者中测序，导致变异率超过5％（可能性为95％），而选择标签SNP进行其余人群的分析。使用学生t检验和方差分析进行统计分析，以检查SNP与存款准备金率之间的关联。发现了四个新颖的​​变体，并且rs11549467的次要等位基因与受试者的RRR相关（p = 0.028）。 rs11549467增加HIF-1α的交易性，增强血管生成并增加新血管的形成。因此，rs11549467可能在导致骨骼重构的平衡紊乱中起重要作用。这项研究的结果可能有助于开发新颖的基因诊断检测方法，并确定在拔牙后容易出现过度下颚萎缩的韩国人。最重要的是，利用遗传信息进行的早期筛查可以使易感患者摆脱下颌骨萎缩的脆弱状况，而后者没有有效的修复方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号