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首页> 外文期刊>Fish & Shellfish Immunology >Effect of a hemiuroid trematode on the hemocyte immune parameters of the cockle Anadara trapezia
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Effect of a hemiuroid trematode on the hemocyte immune parameters of the cockle Anadara trapezia

机译：拟南芥吸虫对鸟蛤Anadara斜方肌血细胞免疫参数的影响

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摘要

When a trematode parasite penetrates a potential molluscan host, it has to circumvent the host's internal defense system. In molluscs, the primary effector cells of this system are the hemocytes which orchestrate many of the cellular and humoral immune functions. Survival of the parasite can occur only in the absence of a successful immune response, and continued development only if the host is physiologically suitable. This study investigated hemocytic response against asexual stages of a hemiuroid trematode by its host, the marine bivalve Anadara trapezia. Hemocyte characteristic (type, morphology) and function (mortality, phagocytosis and oxidative activity) were analyzed by flow cytometry in parasitized and non-parasitized cockles. A. trapezia possesses two types of hemocytes: amebocytes and erythrocytes. Analysis of histological section showed that there was no host hemocytic response around hemiuroid sporocysts. The infection induced a significant increase of the total circulating hemocytes with a higher proportion of erythrocytes relative to amebocytes, coupled with a lower phagocytosis rate and a statistically nonsignificant decrease of the intracellular oxidative activity. No significant differences were observed in hemocyte size and complexity, mortality, or phagocytic capacity. Our results indicate that in A. trapezia, hemiuroids modulate the immune response by increasing the number of circulating hemocytes and decreasing phagocytosis. (C) 2013 Elsevier Ltd. All rights reserved.
机译：当吸虫寄生虫穿透潜在的软体动物宿主时，它必须避开宿主的内部防御系统。在软体动物中，该系统的主要效应细胞是协调许多细胞和体液免疫功能的血细胞。只有在没有成功的免疫反应的情况下才能发生寄生虫的存活，并且只有在宿主生理上合适的情况下才能继续发育。这项研究调查了由寄主海洋双壳类动物Anadara trapezia对类拟南芥吸虫无性阶段的血细胞反应。通过流式细胞仪分析了寄生和未寄生的鸟蛤的血细胞特征（类型，形态）和功能（死亡率，吞噬作用和氧化活性）。梯形假单胞菌具有两种类型的血细胞：变形细胞和红细胞。组织切片的分析表明，在类痔孢子囊周围没有宿主的血细胞反应。感染引起总循环血细胞的显着增加，相对于变形细胞，红细胞的比例更高，同时吞噬率较低，且细胞内氧化活性的统计学上无统计学意义的降低。在血细胞大小和复杂性，死亡率或吞噬能力方面未观察到显着差异。我们的结果表明，在梯形假单胞菌中，类痔通过增加循环血细胞的数量和减少吞噬作用来调节免疫反应。 （C）2013 Elsevier Ltd.保留所有权利。

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