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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice.
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Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice.

机译：博来霉素诱导的小鼠肺纤维化中纤维蛋白对糖皮质激素和2-甲氧基雌二醇的抗性。

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Bleomycin-induced lung fibrosis in mice reproduces some key features of pulmonary fibrosis in humans including alveolar inflammation, myofibroblast proliferation, and collagen deposition. Glucocorticoids have been used as first-line therapy for the treatment of lung fibrosis, although their clinical efficacy is equivocal. We examined the effect of the glucocorticoid, methylprednisolone (MP), and the estrogen metabolite, 2-methoxyestradiol (2MEO) on bleomycin-induced bronchoalveolar inflammation, fibrosis, and changes in lung function. The characterization of the time-course of the bleomycin-induced fibrosis indicated that lung dry mass and hydroxyproline content showed less variance than histopathological assessment of fibrosis. The bleomycin-induced increases in bronchoalveolar lavage (BAL) fluid cell number and protein levels were not significantly influenced by treatment with either MP (1 mg.(kg body mass)(-1).day(-1), i.p.) or 2MEO (50 mg.(kg body mass)(-1).day(-1), i.p.). Lung fibrosis, measured histopathologically or by hydroxyproline content, was not significantly influenced by either MP or 2MEO treatment, whereas the latter agent did reduce the increment in lung dry mass. The enlargement of alveolar airspaces and the decline in lung compliance were exacerbated by MP treatment. These data suggest that bleomycin-induced pulmonary fibrosis is resistant to inhibition by concurrent treatment with either glucocorticoids or 2MEO.
机译：博莱霉素诱导的小鼠肺纤维化在人类中重现了肺纤维化的一些关键特征，包括肺泡炎症，成肌纤维细胞增殖和胶原蛋白沉积。糖皮质激素已被用作治疗肺纤维化的一线疗法，尽管它们的临床疗效是模棱两可的。我们检查了糖皮质激素，甲基强的松龙（MP）和雌激素代谢物2-甲氧基雌二醇（2MEO）对博来霉素诱导的支气管肺泡炎症，纤维化和肺功能变化的影响。博来霉素诱导的纤维化的时程特征表明，肺干质量和羟脯氨酸含量显示出比纤维化的组织病理学评估少的方差。 MP（1 mg。（kg体重）（-1）.day（-1），ip）或2MEO处理对博来霉素诱导的支气管肺泡灌洗液（BAL）液细胞数量和蛋白质水平的增加没有明显影响（50 mg。（kg体重）（-1）.day（-1），ip）。用组织病理学或羟脯氨酸含量测量的肺纤维化不受MP或2MEO处理的影响均显着，而后一种药物的确减少了肺干质量的增加。 MP治疗加剧了肺泡空域的扩大和肺顺应性的下降。这些数据表明博来霉素诱导的肺纤维化对同时用糖皮质激素或2MEO治疗具有抑制作用。

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