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首页> 外文期刊>Fish & Shellfish Immunology >Immune responses of phenoloxidase and superoxide dismutase in the manila clam Venerupis philippinarum challenged with Vibrio tapetis - Part I: Spatio-temporal evolution of enzymes' activities post-infection
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Immune responses of phenoloxidase and superoxide dismutase in the manila clam Venerupis philippinarum challenged with Vibrio tapetis - Part I: Spatio-temporal evolution of enzymes' activities post-infection

机译：马尼拉蛤仔弧菌感染的菲律宾蛤仔中酚氧化酶和超氧化物歧化酶的免疫反应-第一部分：感染后酶活性的时空演变

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摘要

Manila clams, Venerupis philippinarum (Adams and Reeve, 1850), were experimentally challenged with two Vibrio tapetis strains: CECT4600(T), the causative agent of Brown Ring Disease (BRD); and LP2 supposedly non-pathogenic in V. philippinarum. Changes in phenoloxidase (PO) and superoxide dismutase (SOD), two major enzymes involved in immunity, were studied in two tissues, the mantle and hemolymph for 30 days after infection in the extrapallial cavity. Bacterial infection in V. philippinarum resulted in modulation of PO and SOD activities that was both tissue- and time-dependent. A response at early times was detected in the mantle and was associated with significant increases in PO and SOD activities in LP2- and CECT4600(T)-challenged clams 36 h post injection. This first response in the mantle could be explained by the proximity to the injection region (extrapallial cavity). In the hemolymph the response occurred at later times and was associated with an increase in PO activity and a decrease in SOD activity. As hemolymph is a circulating fluid, this response delay could be due to an "integration time" needed by the organism to counteract the infection. Injections also impacted PO and SOD activities in both tissues and confirmed a difference in pathogenicity between the two V. tapetis strains. (C) 2014 Elsevier Ltd. All rights reserved.
机译：马尼拉蛤仔，菲律宾的Venerupis philippinarum（Adams和Reeve，1850年）在实验中受到了两种弧菌的挑战：CECT4600（T），棕环病（BRD）的病原体; LP2和LP2据推测在菲律宾葡萄菌中非致病性。感染后30天，在地幔和淋巴两个组织中研究了涉及免疫力的两种主要酶酚氧化酶（PO）和超氧化物歧化酶（SOD）的变化，持续了30天。菲律宾葡萄菌的细菌感染导致PO和SOD活性的调节与组织和时间有关。注射后36小时，在地幔中检测到早期响应，并且与LP2-和CECT4600（T）攻击的蛤中PO和SOD活性显着增加有关。地幔中的这种第一反应可以通过邻近注射区域（腹膜外腔）来解释。在血淋巴中，反应发生的时间较晚，并且与PO活性的增加和SOD活性的降低有关。由于血淋巴是循环液，这种反应延迟可能是由于生物体抵消感染所需的“整合时间”。注射还影响了两个组织中的PO和SOD活性，并证实了两种V. tapetis菌株之间的致病性差异。 （C）2014 Elsevier Ltd.保留所有权利。

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