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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Inhibitory effects of aqueous extract of Hibiscus sabdariffa on contractility of the rat bladder and uterus.
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Inhibitory effects of aqueous extract of Hibiscus sabdariffa on contractility of the rat bladder and uterus.

机译：芙蓉水提取物对大鼠膀胱和子宫收缩的抑制作用。

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摘要

We examined an aqueous extract of Hibiscus sabdariffa calyces extracts (HSE) by close-arterial injection on micturition thresholds (MTs) and on uterine contractions (rate and amplitude). Five doses of HSE were examined (1, 5, 10, 50, and 100 mg/kg) in 3 groups of rats: controls, after bladder inflammation, and after bilateral hypogastric neurectomy. In some rats, uterine contractions were induced by injection of oxytocin (OT) and the effect of HSE was compared with that of nifedipine. HSE increased MTs in a dose-dependent manner in all groups. Neither atropine (0.1 mg/kg) nor propranolol (0.4 mg/kg) had significant effects on cystometric parameters. They also did not affect the responses obtained by HSE on cystometric parameters. As with bladder response, HSE inhibited both the rate and amplitude of uterine contractions in all groups in a dose-dependent manner. The uterine response to HSE was not affected by administration of either atropine or propranolol. A slight, but significant, reduction of contraction amplitude by HSE in the OT precontracted uteri was only noted at a dose of 500 mg/kg. Nifedipine was more potent than HSE in reducing uterine contraction amplitude. The present work documents inhibition by HSE of the rat bladder and uterine contractility in a dose-dependent manner via a mechanism unrelated to local or remote autonomic receptors or calcium channels. However, further investigation is needed to establish the exact mechanism of action.
机译：我们通过近动脉注射对排尿阈值（MTs）和子宫收缩（速率和振幅）进行了检查，研究了芙蓉花提取物（HSE）的水提取物。在三组大鼠中分别检查了五剂HSE（1、5、10、50和100 mg / kg）：对照组，膀胱发炎后和双侧胃下神经切除术后。在某些大鼠中，通过注射催产素（OT）引起子宫收缩，并将HSE的作用与硝苯地平进行了比较。在所有组中，HSE均以剂量依赖性方式增加MT。阿托品（0.1 mg / kg）和普萘洛尔（0.4 mg / kg）对膀胱测压参数均无显着影响。它们也没有影响HSE在膀胱测压参数上获得的反应。与膀胱反应一样，HSE在所有组中均以剂量依赖性方式抑制子宫收缩的速率和幅度。服用阿托品或普萘洛尔不会影响子宫对HSE的反应。仅在剂量为500 mg / kg时，才注意到OT预收缩子宫中HSE引起的收缩幅度有轻微但显着的降低。硝苯地平在降低子宫收缩幅度方面比HSE更有效。本工作通过与局部或远程自主神经受体或钙通道无关的机制，以剂量依赖的方式记录了HSE对大鼠膀胱和子宫收缩的抑制作用。但是，需要进一步研究以建立确切的作用机制。

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