...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Bone mass, bone strength, and their relationship in developing CD-1 mice.
【24h】

Bone mass, bone strength, and their relationship in developing CD-1 mice.

机译：发育中的CD-1小鼠的骨量，骨强度及其关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Optimizing nutrition during development may provide effective prevention strategies to protect against osteoporosis during later life. Because the mouse model is commonly used to test nutritional interventions on bone health, the overall objective of this study was to determine how bone develops during the first 4 months of life by assessing bone mass (bone mineral content (BMC) and bone mineral density (BMD)) and biomechanical strength properties such as peak load in male and female CD-1 mice. Bone outcomes were assessed at 1 month intervals from 1 to 4 months of age. Femur and spine BMC and BMD at 3 months were similar to 4 months, indicating that the accumulation of bone mass occurs primarily during the first 3 months of life. In contrast, the timing of changes in peak load, a measure of bone strength, varied by skeletal site. Regression analyses demonstrated that femur BMC is a significant predictor of femur peak load at the femur midpoint and neck. The study findings suggest that nutritional interventions aimed at optimizing peak bone mass to prevent osteoporosis may be most effective during pubertal growth.
机译：在发育过程中优化营养可提供有效的预防策略，以预防以后的骨质疏松症。由于小鼠模型通常用于测试对骨骼健康的营养干预措施，因此本研究的总体目标是通过评估骨骼质量（骨骼矿物质含量（BMC）和骨骼矿物质密度（ BMD））和生物力学强度特性，例如雄性和雌性CD-1小鼠的峰值负荷。从1个月到4个月大，每隔1个月评估一次骨结局。 3个月时股骨和脊柱的BMC和BMD与4个月相似，表明骨量的积累主要发生在生命的前3个月。相反，峰值负荷（骨骼强度的度量）变化的时机因骨骼部位而异。回归分析表明，股骨BMC是股骨中点和颈部股骨峰值负荷的重要预测指标。研究结果表明，旨在优化峰值骨质量以预防骨质疏松症的营养干预措施可能在青春期生长期间最为有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号