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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Vascular, renal, and endocrine responses to low-dose atrial natriuretic peptide in the fluid-balanced New Zealand genetically hypertensive rats with and without endogenous arginine vasopressin.
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Vascular, renal, and endocrine responses to low-dose atrial natriuretic peptide in the fluid-balanced New Zealand genetically hypertensive rats with and without endogenous arginine vasopressin.

机译：在有或没有内源性精氨酸加压素的体液平衡的新西兰遗传性高血压大鼠中，对低剂量心房利钠肽的血管，肾脏和内分泌反应。

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摘要

In hypertension, the relationship between atrial natriuretic peptide (ANP) and vasopressin (AVP) is not yet clear, although their renal actions are effectively autoregulation. To examine the possible interaction further, the responses to ANP infusion (75 ng x min (-1), i.v.) have been investigated in both hypertensive and normotensive AVP-replete (HT and NT) and AVP-deficient (HTDI and NTDI) rats. This study aimed to assess the renal function and the plasma hormone concentrations of AVP, angiotensin II (AII), ANP, aldosterone, and corticosterone in the conscious, chronically catheterized, fluid-balanced rats, and to examine the cardiovascular, renal, and endocrine responses to a constant infusion of a low-dose ANP. Data gained from the present study showed, for the first time, the hormone profile, plasma electrolyte composition, and detailed renal function of the servo-controlled, fluid-balanced rats. The similarities of plasma electrolyte composition between servo-controlled and untreated rats indicated that the servo-controlled fluid replacement technique maintained the differences between the strains and maintained body fluid balance during the experimental periods. Following ANP administration, there were no changes in glomerular filtration rate (GFR) in all groups, but an enduring diuresis and natriuresis were observed in HT and NT, which were milder in HTDI rats. However, the hypotensive effect of ANP was of a similar magnitude in all rat strains. HTDI rats exhibited an inhibition of the renin-angiotensin system (RAS), which may have participated in the reduced mean arterial blood pressure (MAP) and natriuresis observed in these rats. The renal actions of ANP appear to rely upon renal tubular events, as indicated by increased fractional electrolyte excretions in the AVP-replete rats. This study highlights the importance of AVP to the profile of the renal actions of ANP in normal rats.
机译：在高血压中，尽管它们的肾功能可以有效地自动调节，但心钠素（ANP）和加压素（AVP）之间的关系尚不清楚。为了进一步检查可能的相互作用，已在高血压和血压正常的AVP补充（HT和NT）和AVP缺乏的（HTDI和NTDI）大鼠中研究了对ANP输注（75 ng x min（-1），iv）的反应。这项研究旨在评估有意识的，长期插管的，体液平衡的大鼠的肾功能和血浆AVP，血管紧张素II（AII），ANP，醛固酮和皮质酮的浓度，并检查心血管，肾脏和内分泌持续输注低剂量ANP的反应。从本研究中获得的数据首次显示了伺服控制的体液平衡大鼠的激素谱，血浆电解质成分和详细的肾功能。伺服控制和未处理大鼠之间血浆电解质成分的相似性表明，在实验期间，伺服控制流体替代技术可保持应变之间的差异并保持体液平衡。施用ANP后，所有组的肾小球滤过率（GFR）均无变化，但HT和NT观察到持久的利尿和利尿作用，而HTDI大鼠则较轻。但是，在所有大鼠品系中，ANP的降压作用均相似。 HTDI大鼠表现出对肾素-血管紧张素系统（RAS）的抑制作用，该系统可能参与了这些大鼠中观察到的平均动脉血压（MAP）和钠尿的降低。 ANP的肾脏作用似乎依赖于肾小管事件，如在AVP充足的大鼠中分数电解质排泄增加所表明的。这项研究强调了AVP对正常大鼠ANP肾功能的影响。

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