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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Nonadrenergic noncholinergic vasodilation of guinea pig pulmonary arteries is mediated by nitric oxide.
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Nonadrenergic noncholinergic vasodilation of guinea pig pulmonary arteries is mediated by nitric oxide.

机译：一氧化氮介导豚鼠肺动脉的非肾上腺能非胆碱能血管舒张。

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摘要

Nonadrenergic noncholinergic (NANC) mediated vasodilation may contribute to the maintenance of low pulmonary vascular tone. The NANC neurotransmitters, nitric oxide (NO) and the sensory neuropeptides, substance P and calcitonin gene related peptide (CGRP), were investigated as possible mediators of NANC vasodilation in guinea pig pulmonary arteries. Fresh guinea pig pulmonary artery rings, with and without an intact endothelium, were mounted in organ baths containing Krebs solution and precontracted with the prostaglandin F2alpha analogue U44069. In both endothelium-intact and denuded vessels, electrical field stimulation (1-12 Hz) in the presence of guanethidine and atropine resulted in a frequency-dependent vasodilation. The peptide fragment hCGRP8-37, a competitive antagonist of the CGRP receptors, the peptide fragment NK1 antagonist SP4-11, and the nonpeptide NK1 antagonist RP67580 had no effect on NANC vasodilation. In both endothelium-intact and denuded vessels, N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthesis, inhibited NANC vasodilation, an effect that was reversible with L-arginine. We conclude that NANC vasodilation in guinea pig pulmonary arteries is mediated predominantly through NO activity.
机译：非肾上腺素能非胆碱能（NANC）介导的血管舒张可能有助于维持低肺血管张力。研究了NANC神经递质，一氧化氮（NO）和感觉神经肽，P物质和降钙素基因相关肽（CGRP）作为豚鼠肺动脉NANC血管舒张的可能介质。将具有和不具有完整内皮的新鲜豚鼠肺动脉环安装在含有Krebs溶液的器官浴中，并与前列腺素F2alpha类似物U44069预收缩。在完整的血管和裸露的血管中，在胍乙啶和阿托品存在的情况下，电场刺激（1-12 Hz）会导致频率依赖性血管舒张。肽片段hCGRP8-37是CGRP受体的竞争性拮抗剂，肽片段NK1拮抗剂SP4-11和非肽NK1拮抗剂RP67580对NANC血管舒张没有影响。在内皮完整和裸露的血管中，N合成抑制剂N（G）-硝基-L-精氨酸甲酯（L-NAME）抑制NANC血管舒张，这是L-精氨酸可逆的。我们得出结论，豚鼠肺动脉中的NANC血管舒张主要是通过NO活性介导的。

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