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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Activation of bulbospinal serotonergic neurons during cold exposure.
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Activation of bulbospinal serotonergic neurons during cold exposure.

机译：低温暴露过程中球根脊髓血清素能神经元的激活。

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摘要

In a four-part study, we expand on our previous report that bulbospinal serotonin (5HT) neuronal activation occurs with 24 h of cold exposure. To characterize temporal aspects, rats were exposed to 3 degrees C or were maintained at 22 degrees C for 2, 8, 48, or 96 h (experiment 1) or for 15, 30, or 60 min (experiment 2). To ensure that cold-induced changes in 5HT activity were not due to disturbances in diurnal pattern, rats in experiment 3 were exposed to cold (8 h) during the dark cycle. To explore the hypothesis that cold-induced 5HT activation is part of a broad metabolic response that includes activation of the sympathetic nervous system, metabolically impaired (hypothyroid) rats were exposed to 8 degrees C in experiment 4. Significant increments in 5-hydroxyindoleacetic acid (SHIAA) concentration were evident by 60 min of cold exposure and existed at all later time points measured. These findings were most robust in spinal cord and rostral brainstem. Activation in spinal cord was also found when rats were exposed to 8 h of cold during the dark cycle, the active period for rats. In experiment 4, hypothyroid rats exhibited significantly greater norepinephrine excretion compared with control rats exposed to the same cold stimulus; this finding was accompanied by significantly greater increments in 5HIAA concentration in rostral brainstem and spinal cord of hypothyroid rats. In addition, significant elevations in tryptophan concentration were noted throughout the brainstem and spinal cord of cold-exposed, hypothyroid rats relative to room temperature, hypothyroid rats. This finding suggested that elevations in 5HIAA concentration in these rats were due to increases in precursor availability. The implications of these findings relative to autonomic and metabolic control are discussed.
机译：在一个由四部分组成的研究中，我们扩展了之前的报告，即低温暴露24小时会发生球根型血清素（5HT）神经元激活。为了表征时间方面，将大鼠暴露于3℃或在22℃下保持2、8、48或96小时（实验1）或15、30或60分钟（实验2）。为了确保冷诱导的5HT活性变化不是由于昼夜模式的紊乱引起的，在黑暗周期中，将实验3的大鼠暴露于寒冷（8小时）中。为了探索这一假设，即冷诱导的5HT活化是广泛的代谢反应（包括交感神经系统活化）的一部分，在实验4中，将代谢受损的（甲状腺功能减退）大鼠暴露于8°C。5-羟基吲哚乙酸显着增加（ SHIAA）浓度在冷暴露60分钟后就很明显，并且在所有后来的时间点都存在。这些发现在脊髓和延髓脑干中最有力。当大鼠在黑暗周期中处于活跃状态时，在黑暗周期中暴露于8 h的寒冷中，也发现了脊髓中的激活。在实验4中，与暴露于相同冷刺激下的对照组大鼠相比，甲状腺功能减退大鼠的去甲肾上腺素排泄量显着增加。这一发现伴随着甲状腺功能减退大鼠的大脑干和脊髓的5HIAA浓度显着增加。另外，相对于室温下的甲状腺功能减退大鼠，冷暴露的甲状腺功能减退大鼠的整个脑干和脊髓中色氨酸浓度显着升高。这一发现表明，这些大鼠中5HIAA浓度的升高是由于前体可用性的增加。讨论了这些发现相对于自主神经和代谢控制的意义。

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