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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome
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Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome

机译：埃及代谢综合征患者中鸢尾素水平与代谢和肝功能的关系

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Irisin is a new myokine that is suspected to influence metabolic syndrome (MetS). However, there is a great controversy with respect to its level in cases of MetS and its correlation with different metabolic parameters. The present study assesses irisin levels in MetS patients and studies its relationship to metabolic and liver functions to evaluate the possible role of the liver in regulation of this level. Sixty subjects were included in this experiment, who were divided into 3 groups: group I (normal control), group II (MetS patients with normal liver enzymes), and group III (MetS with elevated liver enzymes and fatty liver disease). Serum irisin levels showed significant increases in groups II and III compared with group I, and significant increases in group III compared with group II. Also, irisin levels were positively correlated with body mass index, serum triglycerides, homeostatic model assessment of insulin resistance index (HOMA-IR), and liver enzymes. We concluded that serum irisin levels increased in patients with MetS, especially those with elevated liver enzymes, and had a positive correlation with parameters of lipid metabolism and glucose homeostasis with the possibility of hepatic clearance to irisin.
机译：Irisin是一种新的肌动蛋白，被怀疑会影响代谢综合征（MetS）。然而，关于MetS的水平及其与不同代谢参数的相关性，存在很大争议。本研究评估MetS患者的虹膜素水平，并研究其与代谢和肝功能的关系，以评估肝脏在调节该水平方面的可能作用。该实验包括60名受试者，分为3组：第一组（正常对照组），第二组（肝酶正常的MetS患者）和第三组（肝酶升高和脂肪肝的MetS）。与I组相比，II和III组的血清鸢尾素水平显着增加，而III组与II组相比，血清鸢尾素水平显着增加。此外，虹膜素水平与体重指数，血清甘油三酸酯，胰岛素抵抗指数的稳态模型评估（HOMA-IR）和肝酶呈正相关。我们得出的结论是，MetS患者（尤其是肝酶水平升高的患者）的血清虹膜素水平升高，并且与脂质代谢和葡萄糖稳态的参数呈正相关，并可能被肝脏清除。

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