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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Resveratrol reduces matrix metalloproteinases and alleviates intrahepatic cholestasis of pregnancy in rats
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Resveratrol reduces matrix metalloproteinases and alleviates intrahepatic cholestasis of pregnancy in rats

机译：白藜芦醇减少大鼠基质金属蛋白酶并减轻肝内胆汁淤积

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摘要

Intrahepatic cholestasis of pregnancy (ICP) is a severe liver disorder occurring specifically in pregnancy, and matrix metalloproteinase (MMP)-2 and MMP-9 were found to be elevated in ICP patients. Using ethinylestradiol-induced ICP rats as the model, we examined the effect of resveratrol on ICP symptoms such as bile flow rate, serum enzymatic activities, and TBA concentration, as well as MMPlevels, and compared with the known ICP drug ursodeoxycholic acid. Both MMP-2 and MMP-9 were upregulated in ICP rats, and resveratrol treatment could inhibit the elevation of both MMPs, whereas ursodeoxycholic acid did not exhibit any effect. Although ursodeoxycholic acid alleviated ICP symptoms, resveratrol treatment in general exhibited better outcome in restoring bile flow rate, serum enzymatic activities, and TBA concentration. Our results for the first instance strongly supported the potential of RE as a new therapeutic agent in treating ICP, possibly through inhibiting MMP-2 and MMP-9.
机译：妊娠肝内胆汁淤积症（ICP）是一种严重的肝脏疾病，专门发生在妊娠中，并且ICP患者中基质金属蛋白酶（MMP）-2和MMP-9升高。以乙炔雌二醇诱导的ICP大鼠为模型，我们研究了白藜芦醇对ICP症状的影响，例如胆汁流速，血清酶活性和TBA浓度以及MMP水平，并与已知的ICP药物熊去氧胆酸进行比较。 ICP大鼠中MMP-2和MMP-9均被上调，白藜芦醇治疗可以抑制MMPs的升高，而熊去氧胆酸则没有任何作用。尽管熊去氧胆酸减轻了ICP症状，但白藜芦醇治疗通常在恢复胆汁流速，血清酶活性和TBA浓度方面表现出更好的结果。我们的初步结果有力地支持了RE作为治疗ICP的新型治疗剂的潜力，可能是通过抑制MMP-2和MMP-9来实现的。

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