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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Tranilast ameliorates cyclophosphamide-induced lung injury and nephrotoxicity
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Tranilast ameliorates cyclophosphamide-induced lung injury and nephrotoxicity

机译：曲尼司特改善环磷酰胺引起的肺损伤和肾毒性

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摘要

The world-wide increase in cancer incidence imposes a corresponding significant increase in the use of chemotherapeutic agents. Nephrotoxicity is a side effect frequently encountered with cyclophosphamide (CP), which is also well-known to cause acute and chronic lung toxicities. The current study focuses on the evaluation of the potential protective efficacy of tranilast against acute and subacute CP-induced lung and kidney injuries in male Swiss Albino mice. Intraperitoneal CP significantly impaired oxidant/anti-oxidant balance and increased inflammatory cell count in bronchoalveolar lavage fluid, serum creatinine, blood urea nitrogen (BUN), tumor necrosis factor-alpha (TNF-alpha) and lactate dehydrogenase (LDH) levels, with significant impairment of lung and kidney architectures. Tranilast taken orally for 8 and 14 days significantly enhanced mice anti-oxidant defense mechanisms; it increased lung and kidney SOD activity, GSH content and reduced lipid peroxidation. Tranilast significantly reduced serum creatinine and BUN. Furthermore, it decreased accumulation of inflammatory cells in the lungs. Serum TNF-alpha, LDH, total lung and kidney protein contents significantly declined as well. Histopathological examination revealed concomitant significant tissue recovery. Such results show a significant protective potential of tranilast against deleterious lung and kidney damage induced by CP, probably by enhancing host antioxidant defense mechanism, decreasing cytotoxicity, and decreasing expression of inflammatory cytokines.
机译：全世界范围内癌症发病率的增加迫使化学治疗剂的使用相应增加。肾毒性是环磷酰胺（CP）经常遇到的副作用，众所周知，环磷酰胺会引起急性和慢性肺毒性。目前的研究集中在曲尼司特对雄性瑞士白化病小鼠对急性和亚急性CP诱导的肺和肾损伤的潜在保护作用的评估。腹膜内CP严重破坏了支气管肺泡灌洗液，血清肌酐，血尿素氮（BUN），肿瘤坏死因子-α（TNF-α）和乳酸脱氢酶（LDH）水平的氧化剂/抗氧化剂平衡并增加了炎症细胞数量。肺和肾脏结构受损。曲尼司特口服8天和14天可以显着增强小鼠的抗氧化防御机制。它增加了肺和肾脏的SOD活性，GSH含量并减少了脂质过氧化。曲尼司特显着降低血清肌酐和BUN。此外，它减少了肺中炎性细胞的积累。血清TNF-α，LDH，总肺和肾脏蛋白含量也明显下降。组织病理学检查显示伴随显着组织恢复。这些结果表明曲尼司特有可能通过增强宿主抗氧化剂防御机制，降低细胞毒性和降低炎性细胞因子的表达来保护CP诱导的肺和肾脏的有害损害。

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