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首页> 外文期刊>Fish & Shellfish Immunology >Alginate-chitosan-PLGA composite microspheres induce both innate and adaptive immune response through parenteral immunization in fish
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Alginate-chitosan-PLGA composite microspheres induce both innate and adaptive immune response through parenteral immunization in fish

机译：海藻酸盐-壳聚糖-PLGA复合微球通过鱼的肠胃外免疫诱导先天性和适应性免疫反应

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摘要

Alginate-chitosan-PLGA composite microspheres encapsulating outer membrane protein antigen of Aeromonas hydrophila as an antigen carrier was explored for the first time in a fish model. This composite microsphere showed distinct advantages over the conventional PLGA microparticles in aspects of the high encapsulation efficiency due to the protein-friendly microenvironment created by the hydrophilic alginate-chitosan cores of the composite microspheres, preventing initial burst release and the elimination of lyophilizing process. The antibody responses significantly increased and persist up to 9 weeks in composite microspheres unlike that PLGA microsphere, native OMP and FIA adjuvant. Moreover, several innate immune parameters as respiratory burst, lysozyme and complement activity were significantly increased in both composite and PLGA microspheres up to 9 weeks than other treated groups. It also gives protection from A. hydrophila infection and brought some hope, for its application in replacement with conventional PLGA microparticle for antigen delivery in fish. (C) 2013 Elsevier Ltd. All rights reserved.
机译：在鱼类模型中首次探索了封装嗜水气单胞菌外膜蛋白抗原作为抗原载体的藻酸盐-壳聚糖-PLGA复合微球。该复合微球在高封装效率方面表现出优于常规PLGA微粒的独特优势，这归因于复合微球的亲水性藻酸盐-壳聚糖核心所产生的蛋白质友好型微环境，可防止最初的突释和冻干过程的消除。与PLGA微球，天然OMP和FIA佐剂不同，复合微球中的抗体反应显着增加并可持续长达9周。而且，与其他治疗组相比，复合物和PLGA微球中的几个先天免疫参数（如呼吸爆发，溶菌酶和补体活性）在长达9周的时间内均显着提高。它也可以保护其免受亲水性链球菌的感染，并为将其替代常规的PLGA微粒以在鱼类中传递抗原带来了希望。 （C）2013 Elsevier Ltd.保留所有权利。

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