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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Regulation of in vivo whole blood aggregation in rats by calcitonin gene related peptide.
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Regulation of in vivo whole blood aggregation in rats by calcitonin gene related peptide.

机译:降钙素基因相关肽对大鼠体内全血聚集的调节。

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The purpose of these experiments was to determine whether calcitonin gene related peptide (CGRP) mediates physiological control of platelet function in vivo. Rat blood pressure was continuously monitored via a femoral arterial cannula, and whole blood aggregation was assessed periodically ex vivo with an impedance aggregometer before and following a 1.4 nmol/kg bolus dose of CGRP8-37, a specific receptor antagonist of CGRP. Mean arterial blood pressure was not significantly affected by CGRP8-37 over a 30-min period (p>0.05). However, whole blood aggregation increased by 38.4+/-18.0% (p<0.01) and 32.0+/-11.2% (p<0.05), at 5 and 15 min post CGRP8-37, respectively, when compared with control. Whole blood aggregation was not significantly different from control at 30 min (p>0.05), suggesting a relatively short duration of action for in vivo CGRP8-37. These data suggest that CGRP contributes to the maintenance of hemostasis, and that this function may be more important than the better known vasodilatatory effects of this neuropeptide.
机译:这些实验的目的是确定降钙素基因相关肽(CGRP)是否在体内介导血小板功能的生理控制。通过股动脉套管连续监测大鼠血压,并在1.4 nmol / kg推注剂量CGRP8-37(CGRP的特异性受体拮抗剂)之前和之后,通过阻抗凝集仪定期评估全血聚集。在30分钟内,平均动脉血压不受CGRP8-37的显着影响(p> 0.05)。但是,与对照相比,在CGRP8-37后第5和15分钟,全血聚集分别增加了38.4 +/- 18.0%(p <0.01)和32.0 +/- 11.2%(p <0.05)。在30分钟时,全血聚集与对照无显着差异(p> 0.05),表明体内CGRP8-37的作用时间相对较短。这些数据表明,CGRP有助于维持止血,并且该功能可能比该神经肽已知的血管舒张作用更为重要。

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