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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Repeated daily injections and osmotic pump infusion of isoproterenol cause similar increases in cardiac mass but have different effects on blood pressure.
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Repeated daily injections and osmotic pump infusion of isoproterenol cause similar increases in cardiac mass but have different effects on blood pressure.

机译：每天反复注射异丙肾上腺素和渗透泵会引起类似的心脏质量增加，但对血压的影响不同。

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摘要

We found in mice that repeated single daily subcutaneous (s.c.) isoproterenol (ISO) injections, like constant infusions using osmotic minipumps, caused increased biventricular mass or weight relative to body weight (VW/BW). We found that 5 (1/d) s.c. injections of 2, 10, or 20 microg/g body weight caused equivalent VW/BW increases as compared with 5-d infusions at 20 microg/(g.d)). While it is often presumed that ISO elicits hypertrophy by a direct effect on the myocytes, growth may also be secondary to systemic hemodynamic effects. The 2 modes of ISO administration had different effects on mean arterial blood pressure (MABP) and heart rate. Using telemetry we observed that single injections of ISO (0, 0.5, 2, and 10 microg/g) were associated with hypotension and tachycardia with a duration but not a magnitude that was dose dependent. MABP dropped rapidly to 60 mm Hg for more than 2 h at the highest dose. Constant s.c. infusion of ISO at 20 microg/(g.d) initially lowered MABP to about 70 mm Hg for 24 h. At 48 h MABP was normal, but rose 10 mm Hg higher than baseline by day 5. Thus, different routes of administration of ISO that cause comparable increases in VW/BW had different effects on MABP. Thus when evaluating mouse models of ISO-induced cardiac hypertrophy, both repeated daily injections or infusions can cause similar increases in VW/BW, but the daily doses that are required are not the same. Furthermore, these different routes of administration have different hemodynamic sequelae and could potentially evoke different cardiac phenotypes.
机译：我们在小鼠中发现，每天重复皮下注射异丙肾上腺素（ISO）（如使用渗透性微型泵持续输注）会导致双室质量或体重相对于体重（VW / BW）增加。我们发现了5（1 / d）s.c.与以20 microg /（g.d）进行5天输注相比，注射2、10或20 microg / g体重引起的等效VW / BW增加。虽然通常认为ISO通过对心肌细胞的直接作用引起肥大，但生长也可能是系统性血液动力学作用的继发因素。 ISO管理的两种方式对平均动脉血压（MABP）和心率有不同的影响。使用遥测技术，我们观察到单次注射ISO（0、0.5、2和10 microg / g）与低血压和心动过速有关，持续时间与剂量无关，但幅度不大。在最高剂量下，MABP迅速下降至60 mm Hg，持续超过2小时。常数s.c.最初以20 microg /（g.d）注入ISO可使MABP降低至约70 mm Hg，持续24 h。在48小时时，MABP正常，但到第5天比基线升高了10 mm Hg。因此，引起VW / BW相当增加的ISO给药途径对MABP的影响不同。因此，当评估ISO诱发的心脏肥大的小鼠模型时，重复的每日注射或输注都会引起VW / BW的相似增加，但所需的每日剂量却不相同。此外，这些不同的给药途径具有不同的血液动力学后遗症，并可能引起不同的心脏表型。

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