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首页> 外文期刊>Fish & Shellfish Immunology >In vitro toxicity and interactions of environmental contaminants (Arochlor 1254 and mercury) and immunomodulatory agents (lipopolysaccharide and cortisol) on thymocytes from lake trout (Salvelinus namaycush)
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In vitro toxicity and interactions of environmental contaminants (Arochlor 1254 and mercury) and immunomodulatory agents (lipopolysaccharide and cortisol) on thymocytes from lake trout (Salvelinus namaycush)

机译：湖泊鳟鱼（Salvelinus namaycush）胸腺细胞的体外毒性以及环境污染物（Arochlor 1254和汞）和免疫调节剂（脂多糖和皮质醇）的相互作用

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The immunotoxicity of chemical combinations commonly encountered by the lake trout (Salvelinus namaycush) immune system was the focus of this study. It was hypothesised that combinations of an environmental contaminant (mercuric chloride or Aroclor 1254) and an immunomodulatory agent (bacterial endotoxin or cortisol) might interact to produce a greater toxicity than that of the environmental contaminant alone at concentrations typically encountered in piscine blood and other tissues. Thus lake trout thymocytes were isolated and treated with mercuric chloride or Aroclor 1254 in the presence and absence of cortisol or lipopolysaccharide. Incubations were performed for 6 or 20 h at 4 degreesC or 10 degreesC. Lipopolysaccharide did not affect the toxicity of either contaminant. In contrast, cortisol enhanced the toxicity of both environmental contaminants. Hence, stressors that lead to increased cortisol production, but not lipopolysaccharide directly, may increase the toxicity of mercury and Aroclor 1254 to lake trout thymocytes.
机译：本研究的重点是湖鳟（Salvelinus namaycush）免疫系统通常遇到的化学组合的免疫毒性。假设环境污染物（氯化汞或Aroclor 1254）和免疫调节剂（细菌内毒素或皮质醇）的组合可能比在单独的环境污染物（在猪血和其他组织中通常遇到）的相互作用产生更大的毒性。 。因此，分离出湖鳟鱼胸腺细胞，并在存在和不存在皮质醇或脂多糖的情况下用氯化汞或Aroclor 1254处理。在4℃或10℃下孵育6或20小时。脂多糖不影响任何一种污染物的毒性。相反，皮质醇增强了两种环境污染物的毒性。因此，导致皮质醇产生增加而不是直接产生脂多糖增加的压力源可能会增加汞和Aroclor 1254对湖鳟胸腺细胞的毒性。

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