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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The Gurvich waveform has lower defibrillation threshold than the rectilinear waveform and the truncated exponential waveform in the rabbit heart.
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The Gurvich waveform has lower defibrillation threshold than the rectilinear waveform and the truncated exponential waveform in the rabbit heart.

机译：Gurvich波形的除颤阈值低于兔子心脏中的直线波形和截断的指数波形。

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Implantable cardioverter defibrillator studies have established the superiority of biphasic waveforms over monophasic waveforms. However, external defibrillator studies of biphasic waveforms are not as widespread. Our objective was to compare the defibrillation efficacy of clinically used biphasic waveforms, i.e., truncated exponential, rectilinear, and quasi-sinusoidal (Gurvich) waveforms in a fibrillating heart model. Langendorff-perfused rabbit hearts (n = 10) were stained with a voltage-sensitive fluorescent dye, Di-4-ANEPPS. Transmembrane action potentials were optically mapped from the anterior epicardium. We found that the Gurvich waveform was significantly superior (p < 0.05) to the rectilinear and truncated exponential waveforms. The defibrillation thresholds (mean +/- SE) were as follows: Gurvich, 0.25 +/- 0.01 J; rectilinear-1, 0.34 +/- 0.01 J; rectilinear-2, 0.33 +/- 0.01 J; and truncated exponential, 0.32 +/- 0.02 J. Using optically recorded transmembrane responses, we determined the shock-response transfer function, which allowed us to predict the cellular response to waveforms at high accuracy. The passive parallel resistor-capacitor model (RC-model) predicted polarization superiority of the Gurvich waveform in the myocardium with a membrane time constant (taum) of less than 2 ms. The finding of a lower defibrillation threshold with the Gurvich waveform in an in vitro model of external defibrillation suggests that the Gurvich waveform may be important for future external defibrillator designs.
机译：植入式心脏复律除颤器的研究已确立了双相波形优于单相波形的优势。但是，外部除颤器对双相波形的研究并不广泛。我们的目标是比较临床使用的双相波形（即截断的心脏模型中的截断指数，直线和准正弦（Gurvich）波形）的除纤颤功效。用电压敏感的荧光染料Di-4-ANEPPS对Langendorff灌注的兔心脏（n = 10）进行染色。跨膜动作电位从前心外膜光学定位。我们发现，Gurvich波形明显优于直线和截断的指数波形（p <0.05）。除颤阈值（平均值+/- SE）如下：Gurvich，0.25 +/- 0.01 J;直线-1，0.34 +/- 0.01 J;直线2，0.33 +/- 0.01 J;截断指数为0.32 +/- 0.02J。使用光学记录的跨膜响应，我们确定了冲击响应传递函数，这使我们能够高精度地预测细胞对波形的响应。无源并联电阻-电容模型（RC模型）以小于2 ms的膜时间常数（taum）预测了心肌中Gurvich波形的极化优势。在体外除纤颤的体外模型中发现具有Gurvich波形的较低的除纤颤阈值，这表明Gurvich波形可能对未来的体外除纤颤器设计很重要。

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