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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Polymorphonuclear blood leukocytes and restenosis after intracoronary implantation of drug-eluting stents.
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Polymorphonuclear blood leukocytes and restenosis after intracoronary implantation of drug-eluting stents.

机译：冠状动脉内植入药物洗脱支架后的多形核血白细胞和再狭窄。

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摘要

Peripheral blood contents of osteonectin-positive progenitor cells and polymorphonuclear granulocytes were examined by flow cytometry in 38 patients after myocardial revascularisation with drug-eluting stents. Repeat coronary angiography performed 6-12 months after stent implantation revealed in-stent restenosis in 15 patients and its absence in 23 patients. The plasma levels of osteonectin-positive progenitor cells, neutrophils, and basophils did not differ in patients with and without restenosis. Eosinophil blood levels in patients with and without restenosis were 262+/-68 and 124+/-67 cells/microL (mean+/-SD, p<0.001), respectively. Only one of 19 patients (5%) with eosinophil content lower than the distribution median for the entire group developed restenosis, whereas in the group with eosinophil contents higher than the median (n=19) restenosis occurred in 14 patients (74%, p<0.001). Our findings suggest that the frequency of restenoses after stenting is related to high peripheral blood eosinophil content.
机译：通过流式细胞术检测了38例在使用药物洗脱支架进行心肌血运重建后的患者中骨连接素阳性祖细胞和多形核粒细胞的外周血含量。支架植入后6-12个月进行的重复冠状动脉造影显示15例患者存在支架内再狭窄，而23例患者不存在。在有或没有再狭窄的患者中，骨连接蛋白阳性祖细胞，嗜中性粒细胞和嗜碱性粒细胞的血浆水平没有差异。有和没有再狭窄的患者的嗜酸性粒细胞血液水平分别为262 +/- 68和124 +/- 67细胞/微升（平均值+/-标准差，p <0.001）。在整个组中，嗜酸性粒细胞含量低于分布中值的19名患者中只有1例（5％）发生了再狭窄，而在嗜酸性粒细胞含量高于中值（n = 19）的组中，有14位患者发生了再狭窄（74％，p <0.001）。我们的发现表明，支架置入后再狭窄的频率与外周血嗜酸性粒细胞含量高有关。

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