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首页> 外文期刊>Fish & Shellfish Immunology >Mucosal response in African catfish after administration of Vibrio anguillarum O2 antigens via different routes
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Mucosal response in African catfish after administration of Vibrio anguillarum O2 antigens via different routes

机译：通过不同途径施用安圭弧菌O2抗原后非洲cat鱼的粘膜反应

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摘要

The aim of this study was to investigate the possibility of mucosal vaccination in African catfish (Clarias gariepinus) with Vibrio anguillarum O2 bacterins. The antigen was administered via different routes: anal intubation, oral administration, intraperitoneal injection and immersion. To monitor the antigen uptake, a competitive ELISA was used. The antibody response was measured using an indirect ELISA. Increased antibody levels were found in bile and mucus upon anal intubation, which was not the case after intraperitoneal injection. The data indicate that oral vaccination of fish may be possible when antigens can reach the second gut segment in sufficient quantities and in the right form as confirmed by the recorded substantial induction of systemic and mucosal immunity. The results obtained are a strong indication for mucosal immune response and the two compartmental models for immune response in fish.
机译：这项研究的目的是调查用鳗弧菌O2细菌在非洲cat鱼（Clarias gariepinus）中进行粘膜疫苗接种的可能性。抗原通过不同途径给药：肛门插管，口服给药，腹膜内注射和浸泡。为了监测抗原摄取，使用竞争性ELISA。使用间接ELISA测量抗体应答。肛门插管后胆汁和粘液中发现抗体水平升高，腹膜内注射后情况并非如此。数据表明，当抗原能够以足够的数量和正确的形式到达第二肠道段时，可以对鱼进行口服疫苗接种，这已被记录为对全身和粘膜免疫的实质性诱导。获得的结果是粘膜免疫应答和鱼类免疫应答的两个区室模型的有力指示。

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