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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Spontaneous baroreflex sensitivity after coronary artery bypass graft surgery as a function of gender and age.
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Spontaneous baroreflex sensitivity after coronary artery bypass graft surgery as a function of gender and age.

机译：冠状动脉搭桥手术后自发的压力反射敏感性与性别和年龄有关。

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摘要

The effects of coronary artery bypass graft (CABG) surgery on spontaneous baroreflex (SBR) sensitivity and heart rate variability were examined in 11 women and 23 men preoperatively and 5 days postoperatively. Electrocardiograph R-R interval and beat-by-beat arterial blood pressure data were collected continuously for 20 min in the supine and standing postures. Coarse graining spectral analysis was performed on the heart rate variability data. Spontaneous baroreflex sensitivity declined after surgery with a differential influence of gender. Men showed a decrease in SBR slope following surgery, with a greater decrease in the standing posture; the parasympathetic (PNS) indicator was lower postoperatively and in the standing posture; the reduction in low-frequency (LF) power was greater for the younger men. In women, the PNS indicator was lower in the standing posture. Both men and women showed a decrease in high-frequency power following CABG surgery, which decreased the sensitivity of the short-term cardiac control mechanisms that modulate heart rate, with the greater effects occurring in men. The reduction in SBR sensitivity indicates that the ability of the cardiovascular system to respond rapidly to changing stimuli was compromised. The decline in the PNS indicator implies that patients were vulnerable to the risks of myocardial ischemia, sympathetically mediated cardiac dysrhythmias, and sudden cardiac death.
机译：术前和术后5天对11例女性和23例男性进行了冠状动脉搭桥术（CABG）手术对自发性压力反射（SBR）敏感性和心率变异性的影响。以仰卧位和站立位连续20分钟收集心电图仪的R-R间隔和逐次搏动的血压数据。对心率变异性数据进行粗粒度光谱分析。手术后自发的压力反射敏感性下降，并且受到性别的影响。男性在手术后表现出SBR斜率下降，站立姿势下降更大。副交感神经（PNS）指标在术后和站立姿势时较低。年轻人的低频（LF）功率降低幅度更大。在女性中，PNS指标的站立姿势较低。男性和女性在CABG手术后均表现出高频能量下降，这降低了调节心率的短期心脏控制机制的敏感性，对男性的影响更大。 SBR敏感性的降低表明心血管系统对刺激变化的快速反应能力受到损害。 PNS指标的下降表明患者易患心肌缺血，交感神经介导的心律不齐和心源性猝死的风险。

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