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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Myocardial and metabolic dysfunction in type 2 diabetic rats: Impact of ghrelin
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Myocardial and metabolic dysfunction in type 2 diabetic rats: Impact of ghrelin

机译：2型糖尿病大鼠的心肌和代谢功能障碍：ghrelin的影响

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摘要

Diabetes mellitus (DM) is commonly associated with metabolic and cardiac dysfunctions. The aim of this study was to examine the effect of ghrelin on metabolic and cardiac dysfunctions in a type-2 diabetes mellitus (T2DM) rat model. For this, 48 male adult Sprague-Dawley rats were divided equally into 4 groups: Group I, fed normal chow, served as normal control group; Groups II-IV, were fed a high-fat diet for 2 weeks followed by injection of streptozotocin (STZ) (35 mg/kg body mass) to create a model of T2DM; Group II, were not treated; Group III, were treated with the vehicle (saline); Group IV, were treated with ghrelin (40 μg/kg body mass) twice daily for 10 days. The untreated diabetic rats showed a significant increase in serum fasting blood glucose, insulin homeostasis model assessment (HOMA) index, triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), total serum cholesterol (TC), and body mass, with a decrease in high-density lipoprotein cholesterol (HDL-C) (p < 0.05). Hearts isolated from diabetic rats showed a significant increase in myocardial fat content, a significant decrease in GLUT4, and an increase in acyl-CoA oxidase enzyme mRNA (p < 0.05). Ghrelin administration for 10 days caused a significant improvement in lipid profile, HOMA index, and body mass, and significantly corrected the myocardial mass, significantly reduced the fat content of the myocardium, significantly increased GLUT4, and decreased acyl CoA oxidase mRNA (p < 0.05). Thus, ghrelin improves both the metabolic functions and the disturbed energy metabolism in the cardiac muscle of obese diabetic rats.
机译：糖尿病（DM）通常与代谢和心脏功能障碍有关。这项研究的目的是检查生长素释放肽对2型糖尿病（T2DM）大鼠模型代谢和心脏功能障碍的影响。为此，将48只成年雄性Sprague-Dawley大鼠平均分为4组：第一组，喂食正常的食物，作为正常对照组;第二组，喂食正常的食物。对第II-IV组进行高脂饮食2周，然后注射链脲佐菌素（STZ）（35 mg / kg体重）以建立T2DM模型;第二组，未接受治疗;第三组，用媒介物（盐水）治疗;第四组每天用生长素释放肽（40μg/ kg体重）治疗两次，持续10天。未经治疗的糖尿病大鼠血清空腹血糖，胰岛素稳态模型评估（HOMA）指数，甘油三酸酯（TGs），低密度脂蛋白胆固醇（LDL-C），总血清胆固醇（TC）和体重显着增加，高密度脂蛋白胆固醇（HDL-C）降低（p <0.05）。从糖尿病大鼠中分离出的心脏显示，心肌脂肪含量显着增加，GLUT4显着降低，酰基辅酶A氧化酶mRNA显着增加（p <0.05）。施用Ghrelin 10天可显着改善血脂，HOMA指数和体重，并显着纠正心肌质量，显着降低心肌脂肪含量，显着增加GLUT4并降低酰基CoA氧化酶mRNA（p <0.05 ）。因此，生长激素释放肽改善肥胖糖尿病大鼠心肌的代谢功能和能量代谢紊乱。

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