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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Antioxidant characterization of soy derived products in vitro and the effect of a soy diet on peripheral markers of oxidative stress in a heart disease model
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Antioxidant characterization of soy derived products in vitro and the effect of a soy diet on peripheral markers of oxidative stress in a heart disease model

机译：心脏模型中大豆衍生产品的体外抗氧化特性以及大豆饮食对氧化应激周边标志物的影响

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This study analyzed and compared the content of isoflavones in 2 soy products the effectiveness of isoflavones as antioxidants in vitro and demonstrated the antioxidant effect of a soy diet in rats with myocardial infarction (MI). Isoflavone content was analyzed in soybean hypocotyl (SH) and isolated soy protein (ISP). The quality (TAR) and quantity (TRAP) of antioxidants present in the samples was quantified. The amount of daidzin was higher in SH (9 times) and genistein in ISP (5 times). SH presented a 3-fold increase in TAR while both products exhibited same TRAP. The rats were fed an ISP diet for 9 weeks. Animals were distributed among 6 treatment groups: (i) Sham Casein; (ii) Infarct Casein < 25%; (iii) Infarct Casein > 25%; (iv) Sham Soy; (v) Infarct Soy < 25%; and (vi) Infarct Soy > 25%. MI was induced 5 weeks after the commencement of the diets. Lipid peroxidation (LPO) antioxidant enzyme activity and levels of nitritesitrates were determined in blood. Rats receiving the ISP diet demonstrated increased activity of antioxidant enzyme activity and nitrite/ nitrate content. In addition the increase in LPO seen in rats subjected to MI was significantly mitigated when the ISP diet was given. These findings suggest a nutritional approach of using a soy-based diet for the prevention of oxidative-stress-related diseases such as heart failure.
机译：这项研究分析并比较了两种大豆制品中异黄酮的含量以及异黄酮作为抗氧化剂的体外功效，并证明了大豆饮食对心肌梗塞（MI）大鼠的抗氧化作用。在大豆下胚轴（SH）和分离的大豆蛋白（ISP）中分析了异黄酮的含量。对样品中存在的抗氧化剂的质量（TAR）和数量（TRAP）进行了定量。 SH中的大豆苷含量较高（9倍），染料木黄酮的含量较高（5倍）。 SH的TAR增加了3倍，而两种产品的TRAP却相同。给大鼠喂ISP饮食9周。将动物分布在6个治疗组中：（i）Sham Casein; （ii）梗死酪蛋白<25％; （iii）梗死酪蛋白> 25％; （iv）深大豆; （v）梗死大豆<25％; （vi）梗死大豆> 25％。开始饮食后5周诱发MI。测定血液中的脂质过氧化（LPO）抗氧化酶活性和亚硝酸盐/硝酸盐的水平。接受ISP饮食的大鼠表现出增加的抗氧化酶活性和亚硝酸盐/硝酸盐含量。此外，当给予ISP饮食时，MI大鼠的LPO升高明显减轻。这些发现表明，使用大豆饮食来预防诸如心力衰竭等与氧化应激相关的疾病的营养方法。

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