...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Attenuation of endothelin-1-induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells
【24h】

Attenuation of endothelin-1-induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells

机译：姜黄素对A-10血管平滑肌细胞中内皮素1诱导的PKB和ERK1 / 2信号的减弱以及Egr-1的表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Endothelin-1 (ET-1) is implicated in the pathogenesis of vascular abnormalities through the hyperactivation of growth promoting pathways, including protein kinase B (PKB) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. ET-1 has been shown to elicit its responses through the generation of reactive oxygen species (ROS). Curcumin, the main constituent of the spice turmeric, exhibits cardio-protective, anti-proliferative, and antioxidant properties; however, the precise molecular mechanism of its action is unclear. Therefore, in the present study, we investigated the effects of curcumin on ET-1-induced PKB and ERK1/2 signaling, as well as insulin-like growth factor type receptor (IGF-1R) phosphorylation. Curcumin dose-dependently inhibited ET-1-induced phosphorylation of PKB, ERK1/2, c-Raf, and insulin-like growth factor type 1 receptor (IGF-1R), in vascular smooth muscle cells (VSMC). Furthermore, curcumin also attenuated ET-1-induced expression of early growth response (Egr)-1, a transcription factor downstream of ERK1/2 that plays a regulatory role in several cardiovascular pathological processes. In conclusion, these data demonstrate that curcumin is a potent inhibitor of ET-1-induced mitogenic and proliferative signaling events in VSMC and suggest that the ability of curcumin to attenuate these events may contribute as a potential mechanism for its cardiovascular protective response.
机译：内皮素-1（ET-1）通过促进生长的途径（包括蛋白激酶B（PKB）和细胞外信号调节激酶1/2（ERK1 / 2）信号传导）的过度活化而参与了血管异常的发病机理。 ET-1已被证明通过产生活性氧（ROS）引起其反应。姜黄素是香料姜黄的主要成分，具有心脏保护，抗增殖和抗氧化的特性。然而，其作用的确切分子机理尚不清楚。因此，在本研究中，我们研究了姜黄素对ET-1诱导的PKB和ERK1 / 2信号转导以及胰岛素样生长因子型受体（IGF-1R）磷酸化的影响。姜黄素在血管平滑肌细胞（VSMC）中剂量依赖性地抑制ET-1诱导的PKB，ERK1 / 2，c-Raf和胰岛素样生长因子1型受体（IGF-1R）的磷酸化。此外，姜黄素还减弱了ET-1诱导的早期生长反应（Egr）-1的表达，Egr1 / 2是ERK1 / 2下游的转录因子，在几种心血管病理过程中起调节作用。总之，这些数据表明姜黄素是VSMC中ET-1诱导的有丝分裂和增殖信号事件的有效抑制剂，并暗示姜黄素减弱这些事件的能力可能是其心血管保护反应的潜在机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号