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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Human hypoxic ventilatory response with blood dopamine content under intermittent hypoxic training.
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Human hypoxic ventilatory response with blood dopamine content under intermittent hypoxic training.

机译：在间歇性低氧训练下，人的低氧通气反应与血液中的多巴胺含量有关。

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Adaptation to intermittent hypoxia can enhance a hypoxic ventilatory response (HVR) in healthy humans. Naturally occurring oscillations in blood dopamine (DA) level may modulate these responses. We have measured ventilatory response to hypoxia relative to blood DA concentration and its precursor DOPA before and after a 2-week course of intermittent hypoxic training (IHT). Eighteen healthy male subjects (mean 22.8+/-2.1 years old) participated in the study. HVRs to isocapnic, progressive, hypoxic rebreathing were recorded and analyzed using piecewise linear approximation. Rebreathing lasted for 5-6 min until inspired O2 reached 8 to 7%. IHT consisted of three identical daily rebreathing sessions separated by 5-min breaks for 14 consecutive days. Before and after the 2-week course of IHT, blood was sampled from the antecubital vein to measure DA and DOPA content. The investigation associated pretraining high blood DA and DOPA values with low HVR (r = -0.66 and -0.75, respectively), elevated tidal volume (r = 0.58 and 0.37) and vital capacity (r = 0.69 and 0.58), and reduced respiratory frequency (r = -0.89 and -0.82). IHT produced no significant change in ventilatory responses to mild hypoxic challenge (Peto2 from 110 to 70-80 mm Hg; 1 mm Hg = 133.3 Pa) but elicited a 96% increase in ventilatory response to severe hypoxia (from 70-80 to 45 mm Hg). Changes in HVRs were not accompanied by statistically significant shifts in blood DA content (24% change), although a twofold increase in DOPA concentration was observed. Individual subject's changes in DA and DOPA content were not correlated with HVR changes when these two parameters were evaluated in relation to the IHT. We hypothesize that DA flowing to the carotid body through the blood may provoke DA autoreceptor-mediated inhibition of endogenous DA synthesis-release, as shown in our baseline data.
机译：适应间歇性缺氧可以增强健康人的低氧通气反应（HVR）。血液中多巴胺（DA）水平的自然振荡可能会调节这些反应。我们在2周间歇性低氧训练（IHT）前后，测量了相对于血液DA浓度及其前体DOPA的低氧通气反应。 18名健康男性受试者（平均年龄22.8 +/- 2.1岁）参加了该研究。使用分段线性逼近法记录并分析了等碳酸，渐进性，低氧性呼吸的HVR。重新呼吸持续5-6分钟，直到吸入的氧气达到8％至7％。 IHT包括三个相同的每日呼吸练习，间隔5分钟，连续14天。在2周IHT疗程之前和之后，从肘前静脉取血以测量DA和DOPA含量。这项研究将训练前的高血液DA和DOPA值与低HVR（分别为r = -0.66和-0.75），潮气量增加（r = 0.58和0.37）和肺活量（r = 0.69和0.58）以及呼吸频率降低相关（r = -0.89和-0.82）。 IHT对轻度低氧挑战的通气反应无明显变化（Peto2从110升至70-80 mm Hg; 1 mm Hg = 133.3 Pa），但引起严重缺氧的通气反应增加了96％（从70-80 mm至45 mm汞）。尽管观察到的DOPA浓度增加了两倍，但HVR的变化并未伴随血液DA含量的统计学显着变化（变化为24％）。当针对IHT评估这两个参数时，个体受试者DA和DOPA含量的变化与HVR变化无关。我们假设通过血液流到颈动脉的DA可能引起DA自身受体介导的内源性DA合成释放的抑制，如我们的基线数据所示。

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