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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >New insights into body composition assessment in obese women.
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New insights into body composition assessment in obese women.

机译：肥胖女性身体成分评估的新见解。

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During treatment of patients with non-insulin-dependent diabetes mellitus, there may be marked body weight loss. Therefore, body composition should be monitored to check for a decrease in fat mass alone, without an excessive decrease of both fat-free mass and total body water. Accordingly, it is useful to monitor the hydration of these patients. One method that allows us to check the status of body hydration is the multifrequency bioelectric impedance analysis (MFBIA). It makes use of formulas that estimate total body water on the basis of the concept that the human body may be approximated to a cylinder of length equal to body height. In normal subjects body water estimates are sufficiently accurate, but in obese subjects the true hydration status may be overestimated. In this report, we describe the accuracy of mathematical models previously described in the literature, and correct for the overestimation of total body water in obese subjects by means of a new equation based on a new model. The coefficients for each model have been recalculated by the weighing of our sample in order to test the accuracy of estimates obtained with the equations. This new model includes both body volume and two impedances at appropriate frequencies useful for identifying two terms strictly related to extra- and intra-cellular water. The new formulas do not include body weight, but they include the body volume, a parameter more closely related to the biophysical reference model. Fifty-five overweight females, body mass index ranging from 26.8 to 50.2 kg/m2, were enrolled in the study. The proposed equations, taking advantage of two impedance values at appropriate frequencies, better predict total body water in obese women. This was particularly evident when the results obtained with the multifrequency bioelectric impedance analysis and deuterium isotopic oxide dilution method were compared. Although this last method is considered the "gold standard," it is not suitable for use in routine clinical practice. In conclusion, evaluation of total body composition by means of bioelectric impedance analysis might be included in programs for the prevention of non-insulin-dependent diabetes and for monitoring weight loss during overt pathology.
机译：在治疗非胰岛素依赖型糖尿病患者期间，可能会出现明显的体重减轻。因此，应监测身体成分，以仅检查脂肪量是否减少，而无脂肪量和体内总水量不要过度减少。因此，监测这些患者的水合作用是有用的。一种允许我们检查身体水分状况的方法是多频生物电阻抗分析（MFBIA）。它根据人体可以近似为长度等于身高的圆柱体这一概念，使用估算人体总水量的公式。在正常受试者中，体内水分估计值足够准确，但在肥胖受试者中，实际水合状态可能被高估了。在本报告中，我们描述了先前在文献中描述的数学模型的准确性，并通过基于新模型的新方程来纠正肥胖受试者体内总水的高估。每个模型的系数已通过我们的样品称重进行了重新计算，以测试通过这些方程获得的估计值的准确性。这个新模型包括人体体积和适当频率的两个阻抗，可用于识别与细胞外和细胞内水严格相关的两个术语。新公式不包括体重，但包括人体体积，该参数与生物物理参考模型更紧密相关。该研究纳入了55名体重指数在26.8至50.2 kg / m2之间的超重女性。所提出的方程式利用两个频率在适当频率下的阻抗值，可以更好地预测肥胖女性的体内总水分。当比较通过多频率生物电阻抗分析和氘化同位素稀释法获得的结果时，这一点尤其明显。尽管最后一种方法被认为是“黄金标准”，但它不适合常规临床实践使用。总之，通过生物电阻抗分析法评估人体整体成分可能包括在预防非胰岛素依赖型糖尿病和监测明显病理过程中体重减轻的程序中。

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