Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C6) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-alpha-PVP, and phenethylamine derivative 4-methylbuphedrine from illegal products

Nahoko Uchiyama; Satoru Matsuda; Maiko Kawamura; Ruri Kikura-Hanajiri; Yukihiro Goda

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Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C6) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-alpha-PVP, and phenethylamine derivative 4-methylbuphedrine from illegal products

机译：鉴定了两种新型设计药物，哌嗪衍生物MT-45（I-C6）和合成肽Noopept（GVS-111），以及合成大麻素A-834735，卡西酮衍生物4-甲氧基-α-PVP和苯乙胺衍生物4 -非法产品中的甲基甲氧苄啶

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We identified two new-type designer drugs, piperazine derivative MT-45 [1-cyclohexyl-4-(l,2-diphen-ylethyl)piperazine, synonym: I-C6, 1] and synthetic peptide Noopept [ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxamido)acetate, synonym: GVS-111, 2], in chemical and herbal products. MT-45 (1) was previously reported as an opiate-like analgesic substance, and Noopept (2) was reported to have nootropic (cognitive enhancer) activity. We also detected two synthetic cannabinoids, A-834735 (3) and QUPIC N-(5-fluoropentyl) analog (synonym: 5-fluoro-PB-22, 4), in the illegal products. A-834735 (3) was previously reported to act as an agonist at both cannabinoid CB_1 and CB_2 receptors. In addition, cathinone derivative 4-methoxy-alpha-pyrrolidinovalerophenone (4-methoxy-alpha-PVP, 5) and phenethylamine derivative 4-methylbuphedrine (6) were newly detected with known cathinone derivative 4~methylbuphedrone (7) in the products.

机译：我们确定了两种新型设计药物，哌嗪衍生物MT-45 [1-cyclohexyl-4-（1,2-diphen-ylethyl）piperazine，同义词：I-C6，1]和合成肽Noopept [ethyl 2-（1 -（2-苯基乙酰基）吡咯烷-2-甲酰胺基）乙酸盐，同义词：GVS-111，2]，用于化学和草药产品。以前有报道称MT-45（1）是一种鸦片类镇痛药，而有报道Noopept（2）具有促智（认知增强剂）活性。我们还在非法产品中检测到两种合成大麻素A-834735（3）和QUPIC N-（5-氟戊基）类似物（同义词：5-fluoro-PB-22，4）。以前有报道说A-834735（3）在大麻素CB_1和CB_2受体上都起激动剂的作用。此外，在产品中还发现了已知的Cathinone衍生物4〜methylbuphedrone（7），新发现了Cathinone衍生物4-甲氧基-α-吡咯烷基戊二酮（4-甲氧基-α-PVP，5）和苯乙胺衍生物4-甲基丁苯酞（6）。

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《Forensic toxicology》 |2014年第1期|共10页
作者
Nahoko Uchiyama; Satoru Matsuda; Maiko Kawamura; Ruri Kikura-Hanajiri; Yukihiro Goda;
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正文语种 eng
中图分类药学;
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MT-45 1-cyclohexyl-4-(1; 2-diphenylethyl) piperazine; synonym: I-C6; Noopept ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxamido)acetate; synonym: GVS-111; A-834735; 4-Methoxy-alpha-PVP; 4-Methylbuphedrine; QUPIC N-(5-fluoropentyl) analog (synonym: 5-fluoro-PB-22);

机译：MT-45 [1-cyclohexyl-4-（1;2-diphenylethyl）piperazine;同义词：I-C6];Neptept [2-（1-（2-（2-苯基乙酰基）吡咯烷-2-羧酰胺基）乙酸乙酯];同义词：GVS -111];A-834735;4-甲氧基-α-PVP;4-甲基丁啡啶;QUPIC N-（5-氟戊基）类似物（同义词：5-氟-PB-22）;

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专利

1. Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C6) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-alpha-PVP, and phenethylamine derivative 4-methylbuphedrine from illegal products [J] . Nahoko Uchiyama, Satoru Matsuda, Maiko Kawamura, Forensic toxicology . 2014,第1期

机译：鉴定了两种新型设计药物，哌嗪衍生物MT-45（I-C6）和合成肽Noopept（GVS-111），以及合成大麻素A-834735，卡西酮衍生物4-甲氧基-α-PVP和苯乙胺衍生物4 -非法产品中的甲基甲氧苄啶
2. Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products [J] . Nahoko Uchiyama, Yoshihiko Shimokawa, Maiko Kawamura, Forensic toxicology . 2014,第2期

机译：在非法产品中新发现的苯并呋喃衍生物，2-（2-乙基氨基丙基）苯并呋喃（2-EAPB），八种合成大麻素，五种卡西酮衍生物和五种其他名牌药物的化学分析
3. Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products [J] . Nahoko Uchiyama, Maiko Kawamura, Ruri Kikura-Hanajiri, Forensic Toxicology . 2012,第2期

机译：鉴定两种新型合成大麻素-N-（1-金刚烷基）-1-戊基-1H-吲哚-3-羧酰胺（APICA）和N-（1-金刚烷基）-1-戊基-1H-吲唑-3-甲酰胺（APINACA），并检测五种合成大麻素AM-1220，AM-2233，AM-1241，CB-13（CRA-13）和AM-1248，作为非法产品中的设计药物
4. SYNTHETIC STUDY ON DERIVATIVES OF DIMERIC PEPTIDE FROM HUMAN IgG1 HINGE REGION [C] . Petr Niederhafner, Vladimir Gut, Hana Hulacova the European Peptide Symposium . 2007

机译：人IgG1铰链区二聚体肽衍生物的综合研究
5. Synthetic peptide design for functionalized hydrogels: Development of cellularly responsive drug delivery platforms and cyclic, multivalent peptide derivatives using radical-mediated thiol-ene/thiol-yne chemistries. [D] . Aimetti, Alex Arthur. 2010

机译：功能化水凝胶的合成肽设计：使用自由基介导的硫醇-烯/硫醇-炔化学方法开发细胞响应性药物递送平台和环状多价肽衍生物。
6. A synthetic cannabinoid FDU-NNEI two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18) a phenethylamine derivative N–OH-EDMA and a cathinone derivative dimethoxy-α-PHP newly identified in illegal products [O] . Nahoko Uchiyama, Yoshihiko Shimokawa, Ruri Kikura-Hanajiri, -1

机译：合成大麻素FDU-NNEI合成大麻素AB-CHMINACA和NNEI吲唑类似物（MN-18）的两个2H-吲唑异构体苯乙胺衍生物N-OH-EDMA和卡西酮衍生物二甲氧基-α-PHP非法产品
7. A synthetic cannabinoid FDU-NNEI, two 2-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative –OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products [O] . 2015

机译：合成大麻素FDU-NNEI，合成大麻素AB-CHMINACA和NNEI吲唑类似物（MN-18）的两个2-吲唑异构体，苯乙胺衍生物-OH-EDMA和卡西酮衍生物二甲氧基-α-PHP产品展示

Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C6) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-alpha-PVP, and phenethylamine derivative 4-methylbuphedrine from illegal products

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