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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Insulin sensitivity regulated by feeding in the conscious unrestrained rat.
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Insulin sensitivity regulated by feeding in the conscious unrestrained rat.

机译：通过进食有意识的无拘束大鼠来调节胰岛素敏感性。

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Hepatic insulin sensitizing substance (HISS), a putative hormone released from the liver in response to insulin in fed animals, accounts for 50-60% of insulin action. HISS release is regulated by permissive control of the hepatic parasympathetic nerves. The objectives were to develop the rapid insulin sensitivity test (RIST) in conscious rats, and to assess the effects of anesthesia, atropine, feeding, and fasting on insulin action. The RIST index, expressed as milligrams glucose per kilogram body weight required to maintain euglycemia after a 50 mU/kg bolus of insulin, was similar in conscious and anesthetized rats (238.6+/-42.5 vs. 225.3+/-30.4 mg/kg). Atropine produced a 56% inhibition of insulin action in fed rats. After a 24 h fast, full HISS-dependent insulin resistance had developed as shown by a low RIST index that was not reduced further by atropine. Fasting caused a 10.5% decrease in insulin action per hour over six hours. HISS-dependent insulin resistance in 24-h fasted rats was reversed 4 h after re-feeding (90.9+/-12.3 vs. 204.5+/-30.5 mg/kg). We conclude that HISS-dependent and HISS-independent insulin action, as assessed by the RIST, is similar in conscious and pentobarbital-anesthetized rats. Pharmacological blockade of HISS-dependent insulin action and physiological regulation of HISS action by feeding-fasting is confirmed. Re-feeding fasted rats reversed HISS-dependent insulin resistance. Merits of use of the RIST in conscious versus anesthetized rats are discussed.
机译：肝胰岛素敏化物质（HISS）是一种在饲喂动物中响应胰岛素而从肝脏释放的推定激素，占胰岛素作用的50-60％。 HISS的释放受肝脏副交感神经的控制。目的是开发神志清楚的大鼠的快速胰岛素敏感性测试（RIST），并评估麻醉，阿托品，进食和禁食对胰岛素作用的影响。在清醒和麻醉的大鼠中，RIST指数以维持50 mU / kg胰岛素后维持正常血糖所需的每千克体重毫克葡萄糖表示（238.6 +/- 42.5 vs. 225.3 +/- 30.4 mg / kg） 。阿托品对进食大鼠产生56％的胰岛素作用抑制作用。禁食24小时后，已出现完全HISS依赖的胰岛素抵抗，如低RIST指数所示，阿托品并没有进一步降低它。空腹在六个小时内每小时导致胰岛素作用下降10.5％。再次喂食后4 h，空腹24 h大鼠中HISS依赖的胰岛素抵抗被逆转（90.9 +/- 12.3 vs. 204.5 +/- 30.5 mg / kg）。我们得出的结论是，由RIST评估的HISS依赖性和HISS依赖性胰岛素作用在有意识和戊巴比妥麻醉的大鼠中相似。确认了通过喂食禁食可以抑制HISS依赖性胰岛素作用的药理作用和对HISS作用的生理调节。重新喂食禁食的大鼠逆转了HISS依赖的胰岛素抵抗。讨论了在有意识的和麻醉的大鼠中使用RIST的优点。

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