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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The effect of nicotine on in vitro placental perfusion pressure.
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The effect of nicotine on in vitro placental perfusion pressure.

机译：尼古丁对体外胎盘灌注压力的影响。

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摘要

Cigarette smoking throughout pregnancy is associated with several negative outcomes, of which an increased incidence of intra-uterine growth restriction (IUGR) is most pronounced. Gestationally age-matched infants born to smoking mothers are, on average, 200 g lighter at birth, per pack smoked per day. The mechanisms and specific tobacco compounds responsible for the increased risk of IUGR among smokers have yet to be identified; however, it is widely accepted that smoking women have compromised placental perfusion throughout gestation due to the vasoconstricting effect of nicotine on uterine and placental blood vessels. Despite the universal acceptance of this theory, very little work has been completed to date examining the vasoactive properties of nicotine within the human placenta. The objective of this study was to determine the effect of nicotine on placental vascular function. Normal-term human placentae were obtained after elective cesarean sections. An in vitro placental perfusion system was used; increasing doses of nicotine (20-240 ng/mL) were added to either the maternal (n = 5) or fetal (n = 3) circulation. The basal feto-placental perfusion pressure was 39.87 +/- 4.3 mmHg and was not affected by nicotine. This finding supports the hypotheses that nicotine does not directly affect placental microvascular function and that any contribution to fetal growth restriction is likely at the level of placental function (i.e., amino acid transport) and (or) uterine vascular function.
机译：整个怀孕期间吸烟与几种不良后果有关，其中最明显的是宫内生长受限（IUGR）发生率增加。每天抽烟每包，吸烟母亲所生的与胎龄匹配的婴儿平均体重减轻200 g。尚不清楚导致吸烟者中IUGR风险增加的机制和特定烟草化合物;然而，由于尼古丁对子宫和胎盘血管的血管收缩作用，吸烟妇女在整个妊娠期损害了胎盘灌注。尽管该理论已被普遍接受，但迄今为止，几乎没有完成检查人胎盘中尼古丁的血管活性的工作。这项研究的目的是确定尼古丁对胎盘血管功能的影响。选择性剖宫产后获得正常人胎盘。使用体外胎盘灌注系统。将增加剂量的尼古丁（20-240 ng / mL）添加到孕妇（n = 5）或胎儿（n = 3）循环中。胎儿胎盘基础灌注压力为39.87 +/- 4.3 mmHg，不受尼古丁影响。该发现支持以下假设：尼古丁不会直接影响胎盘微血管功能，并且对胎儿生长限制的任何贡献可能都在胎盘功能（即氨基酸转运）和（或）子宫血管功能的水平上。

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